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Procalcitonin-guided antibiotic treatment in patients with cancer: a patient-level meta-analysis from randomized controlled trials.
BMC Cancer
November 2024
Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.
Background: Use of serum procalcitonin (PCT), an inflammatory biomarker for bacterial infections, has shown promising results for early stopping antibiotic treatment among patients with respiratory infections and sepsis. There is need for additional data regarding effectiveness and safety of this concept among patients with cancer.
Methods: Individual data of patients with a documented diagnosis of cancer and proven or suspected respiratory infection and/or sepsis were extracted from previous trials where adult patients were randomized to receive antibiotic treatment based on a PCT protocol or usual care (control group).
Procalcitonin-guided antimicrobial stewardship in critically ill patients with sepsis: A pre- post interventional study.
Perspect Clin Res
February 2024
Department of Critical Care, Believers Church Medical College Hospital, Thiruvalla, Kerala, India.
Aim: Injudicious usage of antibiotics has led to the emergence of antibiotic resistance which is a major health-care problem in developing countries such as India. Our aim was to show how antibiotic therapy based on serial procalcitonin (PCT) assay can help in antibiotic de-escalation in septic patients.
Materials And Methods: A pre-post interventional study was conducted among 300 septic patients admitted to an intensive care unit (ICU).
Background: Procalcitonin-guided antimicrobial decision-making has been shown to be safe in adult intensive care settings. Most antimicrobial exposure in neonatal units is in culture-negative conditions. We hypothesise that Procalcitonin aids antimicrobial stewardship efforts in suspected Late-Onset Neonatal Sepsis.
View Article and Find Full Text PDFProcalcitonin-Guided Management and Duration of Antibiotic Therapy in Critically Ill Cancer Patients With Sepsis (Pro-Can Study): A Randomized Controlled Trial.
Crit Care Explor
October 2024
School of Clinical Sciences, Monash University, Melbourne, VIC, Australia.
Objectives: To evaluate the effect of procalcitonin-guided management on the duration of antibiotic therapy in critically ill cancer patients with sepsis.
Design: Randomized, controlled, single-blinded trial.
Setting: A comprehensive multidisciplinary cancer hospital in Jordan.
Benefits and Harms of Procalcitonin- or C-Reactive Protein-Guided Antimicrobial Discontinuation in Critically Ill Adults With Sepsis: A Systematic Review and Network Meta-Analysis.
Crit Care Med
October 2024
Department of Emergency and Critical Care Medicine, Juntendo University Urayasu Hospital, Urayasu, Japan.
Objectives: In sepsis treatment, antibiotics are crucial, but overuse risks development of antibiotic resistance. Recent guidelines recommended the use of procalcitonin to guide antibiotic cessation, but solid evidence is insufficient. Recently, concerns were raised that this strategy would increase recurrence.
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