The conducting myocardia of the sinus node and prenodal working ones of the right atrium, which had been dissected from 6 patients aged 10-40 years with the prolonged Q-T interval syndrome during an operation on implantation of an artificial pacemaker were examined. Acute and chronic destructive changes were found in the conducting and working myocytes of the sinoauricular region in the heart. Some cases displayed abnormal contact interrelationships of myocytes. Destructive changes were observed in non-myelinated and myelinated nerve fibers, microcirculatory bed, and the connective tissue component of the conducting and working myocardium. The abnormalities found in the cardiac sinoauricular region are discussed to be a possible substrate for the development of life-threatening arrhythmias in patients with the prolonged Q-T interval syndrome.
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bioRxiv
November 2024
Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Endocr Pract
November 2024
Department of Urology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. Electronic address:
Objective: Mitotane is currently the only product approved by the Food and Drug Administration for the treatment of adrenocortical cancer. However, there is a lack of comprehensive studies on the adverse events of mitotane.
Methods: Adverse event reports for mitotane in the Food and Drug Administration Adverse Event Reporting System database since 2004 were collected and analyzed to identify mitotane as the primary suspect drug.
Future Oncol
October 2024
Department of Pharmacy, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China.
We conducted network meta-analysis to assess cardiovascular toxicity of anaplastic lymphoma kinase-tyrosine kinase inhibitors (-TKIs). Eleven articles involving 2855 patients and six interventions including crizotinib, alectinib, ceritinib, lorlatinib, brigatinib and chemotherapy were analyzed. No significant difference was observed in overall cardiovascular risk among -TKIs.
View Article and Find Full Text PDFCommun Chem
July 2024
Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, 208016, UP, India.
Globally, millions of diabetic patients require daily life-saving insulin injections. Insulin heat-lability and fibrillation pose significant challenges, especially in parts of the world without ready access to uninterrupted refrigeration. Here, we have synthesized four human insulin analogs by conjugating ε-amine of B29 lysine of insulin with acetic acid, phenylacetic acid, alanine, and phenylalanine residues.
View Article and Find Full Text PDFEpilepsy Behav
August 2024
University of Buenos Aires, Faculty of Pharmacy and Biochemistry, Institute of Phisiopatology and Clinical Biochemistry (INFIBIOC), Applied Neurobiology Lab, Buenos Aires, Argentina. Electronic address:
Iron is a crucial element for almost all organisms because it plays a vital role in oxygen transport, enzymatic processes, and energy generation due to its electron transfer capabilities. However, its dysregulation can lead to a form of programmed cell death known as ferroptosis, which is characterized by cellular iron accumulation, reactive oxygen species (ROS) production, and unrestricted lipid peroxidation. Both iron and ferroptosis have been identified as key players in the pathogenesis of various neurodegenerative diseases.
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