AI Article Synopsis
- The study aimed to determine how effective hemoglobin A (HbA) levels are in screening for different types of thalassemia among 2,000 adults in Guangdong.
- Researchers collected blood samples and analyzed HbA using an automatic technique, also checking the genotypes for thalassemia.
- Findings revealed specific HbA cutoff values for identifying various thalassemia forms, with excellent screening accuracy for intermedia α-thalassemia and β-thalassemia traits indicated by ROC curve analysis.
Article Abstract
Objective: To investigate the value of hemoglobin A(HbA) for screening thalassemia.
Methods: A total of 2 000 adults' peripheral blood samples from Guangdong Women and Children Hospital from June 2013 to January 2014 were collected. The hemoglobin A (HbA) level was analyzed by the full automatic capillary electrophoresis technique, and the genotypes of thalassemia were detected.
Results: The optimal cutoff values of HbA for screening silent α-thalassemia, α-thalassemia trait, intermedia α-thalassemia and β-thalassemia trait were 2.85%, 2.65%, 2.25% and 3.45%, respectively; the areas under receiver operator characteristic (ROC) curve were 0.709, 0.839, 0.979 and 0.997 respectively; the sensitivities were 0.481, 0.721, 0.953 and 0.994, and the specificities were 0.846, 0.837, 0.929 and 0.969 respectively.
Conclusion: The optimal cutoff values of HbA for screening different type of thalassemia based on our laboratory data are established by using ROC curve. According to the area under ROC curve, a satisfactory accuracy for screening intermedia α-thalassemia and β-thalassemia trait can be achieved by detecting hemoglobin A level.
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| http://dx.doi.org/10.7534/j.issn.1009-2137.2016.06.038 | DOI Listing |
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