[Effect of WT1 Gene High Expression and CD34 and Auer on Prognosis of Acute Myeloid Leukemia].

Objective: To explore the clinical significance of WT1 expression level in patient with AML non-M3,understand the biological characteristics of Auer and CD34 AML and its effects on first induced remission rate and prognosis.

Methods: The RQ-PCR was used to detect the WT1 expression levels in 92 patients suffering AML non-M3; the relationship between the CR1 and OS was analysed and the differences of CR1 and OS in AML with Auer and Auer,CD34 and CD34 were compared.

Results: AML with WT1 high expression level at first visit had quite lower CR1 (P<0.05). AML with CD34 had quite lower CR1 (P<0.05). Compared with Auer patients, CR1 of Auer CML patients was higher (P<0.05), the OS of AML patients with WT1 high expression level was lower than that of the AML patients with low expression level of WT1, and with significant differences (P<0.05), the OS of AML patients with CD34 was lower than that of AML patients with CD34, and with significant differences (P<0.05). There was no obvious difference in OS between the AML patients with Auer and Auer.

Conclusion: High expression level of WT1 and CD34 in AML patients suggests the poor prognosis. The Auer positive only relats with CR1, and does not relate with OS.