The recent observation of interviral recombination between members of two distinct classes of DNA viruses has opened the gates to a new field of human disease development. In all cases studied thus far interviral recombination is a rare event that requires special circumstances for intracellular interaction of participating viral genomes. The rarity and special requirements do not detract from the potential clinical significance of resulting recombinants, as exemplified by recombination between JC viral and Epstein-Barr viral genomes. This significance depends largely upon the mechanisms of recombination that would generate specific forms of recombinant viral genomes. At this time little is known regarding mechanisms of interviral recombination. DNA break-induced replication seems presently to be a highly plausible means of initiating formation of different, potentially active recombination products. Generalizing interviral recombination to a variety of viruses will open a fertile field for discovery as multiple diseases of mysterious etiology are investigated.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180597 | PMC |
| http://dx.doi.org/10.4172/2168-975X.1000217 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Interviral Recombination between Plant, Insect, and Fungal RNA Viruses: Role of the Intracellular Ca/Mn Pump.
J Virol
December 2019
Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, USA
Recombination is one of the driving forces of viral evolution. RNA recombination events among similar RNA viruses are frequent, although RNA recombination could also take place among unrelated viruses. In this paper, we have established efficient interviral recombination systems based on yeast and plants.
View Article and Find Full Text PDFGenetically highly divergent RNA virus with astrovirus-like (5'-end) and hepevirus-like (3'-end) genome organization in carnivorous birds, European roller (Coracias garrulus).
Infect Genet Evol
July 2019
Department of Medical Microbiology and Immunology, Medical School, University of Pécs, Pécs, Hungary. Electronic address:
Astroviruses (family Astroviridae) and hepeviruses (family Hepeviridae) are small, non-enveloped viruses with genetically diverse +ssRNA genome thought to be enteric pathogens infecting vertebrates including humans. Recently, many novel astro- and hepatitis E virus-like +ssRNA viruses have been described from lower vertebrate species. The non-structural proteins of astro- and hepeviruses are highly diverse, but the structural/capsid proteins represent a common phylogenetic position shed the light of their common origin by inter-viral recombination.
View Article and Find Full Text PDFDetection of a novel RNA virus with hepatitis E virus-like non-structural genome organization in amphibian, agile frog (Rana dalmatina) tadpoles.
Infect Genet Evol
November 2018
Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses, ÁNTSZ Regional Institute of State Public Health Service, Pécs, Hungary; Department of Medical Microbiology and Immunology, Medical School, University of Pécs Pécs, Hungary.
In recent years, relatives (bastrovirus, hepelivirus) of hepeviruses (family Hepeviridae) have been reported in a variety of vertebrate hosts. Preliminary studies indicated that inter-viral family recombination events at the junction of the genomes that encodes non-structural (ORF1) and structural protein (ORF2) were implicated in the genesis of hepeviruses. Using viral metagenomics, next generation sequencing and RT-PCR techniques a genetically divergent hepevirus-like RNA virus was identified and characterized from agile frog (Rana dalmatina) tadpoles living in aquatic environment in three natural ponds (Mélymocsár, Lake Ilona and Lake Katlan) in the Pilis Mountains, in Hungary.
View Article and Find Full Text PDFSignificance of Interviral Recombination as Novel Mechanism for Extending Viral Disease Repertoire.
Brain Disord Ther
October 2016
Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
The recent observation of interviral recombination between members of two distinct classes of DNA viruses has opened the gates to a new field of human disease development. In all cases studied thus far interviral recombination is a rare event that requires special circumstances for intracellular interaction of participating viral genomes. The rarity and special requirements do not detract from the potential clinical significance of resulting recombinants, as exemplified by recombination between JC viral and Epstein-Barr viral genomes.
View Article and Find Full Text PDFAncient recombination events and the origins of hepatitis E virus.
BMC Evol Biol
October 2016
School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, NSW, Australia.
Background: Hepatitis E virus (HEV) is an enteric, single-stranded, positive sense RNA virus and a significant etiological agent of hepatitis, causing sporadic infections and outbreaks globally. Tracing the evolutionary ancestry of HEV has proved difficult since its identification in 1992, it has been reclassified several times, and confusion remains surrounding its origins and ancestry.
Results: To reveal close protein relatives of the Hepeviridae family, similarity searching of the GenBank database was carried out using a complete Orthohepevirus A, HEV genotype I (GI) ORF1 protein sequence and individual proteins.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!