Fat embolism syndrome presented with the classical triad of respiratory manifestations (95%), cerebral effects (60%) and Petechial rash (33%). Focal neurological symptoms in the form of combined bilateral cortical blindness and motor aphasia even prior to respiratory symptoms have been never reported in previous literature. We describe a case of these rare focal neurological symptoms secondary to the fat embolism syndrome in a young adult male following closed femur fracture.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167514PMC
http://dx.doi.org/10.1016/j.jcot.2016.10.010DOI Listing

Publication Analysis

Top Keywords

fat embolism
12
embolism syndrome
12
cortical blindness
8
blindness motor
8
motor aphasia
8
focal neurological
8
neurological symptoms
8
aphasia unusual
4
unusual presentation
4
presentation fat
4

Similar Publications

Safety, bactericidal activity, and pharmacokinetics of the antituberculosis drug candidate BTZ-043 in South Africa (PanACEA-BTZ-043-02): an open-label, dose-expansion, randomised, controlled, phase 1b/2a trial.

Lancet Microbe

December 2024

Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Germany; German Center for Infection Research, Munich Partner Site, Munich, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection, and Pandemic Research, Munich, Germany; Unit Global Health, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Electronic address:

Background: The broad use of bedaquiline and pretomanid as the mainstay of new regimens to combat tuberculosis is a risk due to increasing bedaquiline resistance. We aimed to assess the safety, bactericidal activity, and pharmacokinetics of BTZ-043, a first-in-class DprE1 inhibitor with strong bactericidal activity in murine models.

Methods: This open-label, dose-expansion, randomised, controlled, phase 1b/2a trial was conducted in two specialised tuberculosis sites in Cape Town, South Africa.

View Article and Find Full Text PDF

Background: Autologous fat grafting in the buttocks has gained great popularity However, one of the main risks is infiltration of fat into the systemic venous system, leading to potential complications such as macroscopic fatty embolism (MAFE), which can be fatal.

Objectives: This study evaluated the safety and efficacy of the LiRi (Linear Retrograde infiltration) for autologous fat grafting in the buttocks, and its evolution over a six-month follow-up period.

Methods: The procedure was performed in 114 patients.

View Article and Find Full Text PDF
Article Synopsis
  • The study explored how extracellular histone H4 contributes to acute respiratory distress syndrome (ARDS) triggered by oleic acid (OA) in mice.
  • The research found that levels of histone H4 increased significantly after OA injection, correlating with the severity of ARDS, and that pre-treatment with histone H4 worsened lung edema and mortality.
  • Histone H4 activated endothelial cells through mechanisms involving heparan sulfate degradation and certain receptors, leading to inflammation and thrombus formation in the lungs.
View Article and Find Full Text PDF

Background: Autologous fat transplantation has gained increasing attention in the field of cosmetic surgery. However, a series of complications can occur after fat transplantation.

Case Presentation: A 24-year-old woman presented at our Hospital with nasal skin necrosis and ulceration.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!