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Low-Dose Emicizumab Versus Low-/Intermediate-Dose Factor VIII Secondary Prophylaxis for Noninhibitor Haemophilia A Patients With Severe Bleeding Phenotype.
Haemophilia
December 2024
Division of Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Background: Subcutaneous emicizumab, a factor VIII (FVIII)-mimicking bispecific monoclonal antibody, can effectively prevent bleeds in haemophilia A (HA) patients with/without inhibitors; however, its standard-dose regimens are financially burdensome. Low-dose emicizumab prophylaxis may alternatively be applied to noninhibitor HA patients in resource-limited settings.
Methods: During 2023, Thai patients with noninhibitor severe HA or moderate HA with severe bleeding phenotype (historical annualized bleeding rate [ABR] >5 bleeds/year before regular FVIII prophylaxis) who received low-/intermediate-dose FVIII secondary prophylaxis ≥8 months were enrolled.
Coffee and tea consumption and glioma risk: a meta-analysis of cohort studies.
Front Nutr
December 2024
Department of Neurosurgery, Chongqing General Hospital, Chongqing University, Chongqing, China.
Background: Research on the association between glioma risk and coffee and tea consumption remains inconclusive. This study seeks to present a meta-analysis of the relationship between coffee and tea intake and glioma risk.
Method: Relevant cohort studies that collected coffee and tea exposure prospectively were identified through searches of the PubMed, Embase, and Scopus databases.
Comparative reinfection rate of one-stage versus two-stage revision in the management of periprosthetic joint infection following total hip arthroplasty: a meta-analysis.
BMC Musculoskelet Disord
December 2024
The First Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, 124 Yuejin Road, Liuzhou, Guangxi Province, 545001, China.
Background: Debates persist on the optimal surgical approach for treating Periprosthetic joint infection (PJI) following total hip arthroplasty (THA). This meta-analysis aimed to compare the reinfection rate of one-stage revision versus two-stage revision for PJI after THA.
Methods: A comprehensive search was performed in four databases (PubMed, Embase, Web of Science, and Cochrane Library) to locate articles that assessed the reinfection rate of one-stage revision compared to two-stage revision.
Difficulty of diagnostic accuracy of periprosthetic joint infection: a retrospective analysis of revision surgery of total hip arthroplasty and total knee arthroplasty in a tertiary hospital.
BMC Musculoskelet Disord
December 2024
Department of Orthopaedic Surgery, Katholisches Klinikum Bochum, Ruhr-University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany.
Background: Diagnostic accuracy of periprosthetic joint infection still remains controversial and an unsolved problem with respect to clinical signs and laboratory measures. Influencing factors of diagnosis like age, sex, abnormal physical findings and comorbidities are published with different results. The aim of our study was to find factors strengthening the diagnosis.
View Article and Find Full Text PDFEvaluating the Cumulative Benefit of Inspiratory CT, Expiratory CT, and Clinical Data for COPD Diagnosis and Staging through Deep Learning.
Radiol Cardiothorac Imaging
December 2024
From the Computational Science Research Center, San Diego State University, San Diego, Calif (A.N.L.); Department of Radiology, University of California San Diego, La Jolla, Calif (A.H.); and Department of Mathematics and Statistics, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182 (K.A.H.).
Purpose To measure the benefit of single-phase CT, inspiratory-expiratory CT, and clinical data for convolutional neural network (CNN)-based chronic obstructive pulmonary disease (COPD) staging. Materials and Methods This retrospective study included inspiratory and expiratory lung CT images and spirometry measurements acquired between November 2007 and April 2011 from 8893 participants (mean age, 59.6 years ± 9.
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