AI Article Synopsis
- Van der Woude syndrome (VWS) is the most common syndromic cleft lip and palate (SCLP), affecting about 2% of CLP patients.
- The case involves an orthodontic treatment for a girl with VWS, focusing on addressing her cosmetic concerns.
- Treatment included various surgical and orthodontic procedures, with genetic testing identifying a specific mutation as the cause, highlighting the importance of an interdisciplinary approach and parental counseling.
Article Abstract
Introduction: Van der Woude syndrome (VWS) is the most frequent form of syndromic cleft lip and palate (SCLP) accounting for 2% of all patients with CLP.
Case Presentation: We describe the orthodontic treatment of a girl diagnosed with VWS referred by her family dentist for her cosmetic concerns.
Discussion: Comprehensive orthodontic treatment, secondary bone graft, distraction osteogenesis (for a deficient maxilla), secondary palatoplasty and excision of lower lip pits, as well as orthodontic and prosthetic procedures may provide a satisfactory outcome. Genetic testing showed a known putative splice site mutation (c.174+1G/A) as the prime cause of VWS in our patient and her family.
Conclusion: SCLP has significant effects on facial aesthetics and the psychosocial status. Parents should be assessed and counseled appropriately. This condition is treatable in the absence of life threatening systemic anomalies. An interdisciplinary team approach is advocated.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192017 | PMC |
| http://dx.doi.org/10.1016/j.ijscr.2016.11.032 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intravascular lithotripsy in heavily calcified chronic total occlusion: procedural and one-year clinical outcomes.
Catheter Cardiovasc Interv
October 2024
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Article Synopsis
- The study investigates the use of intravascular lithotripsy (IVL) in treating heavily calcified chronic total occlusions (CTOs), noting that calcification leads to worse patient outcomes.
- It analyzes data from 404 patients, finding that procedural success rates and safety outcomes were similar for both CTO and non-CTO patients.
- The conclusion emphasizes that IVL is effective and safe for managing heavily calcified lesions, supporting its use in clinical practice.
An optimized b-value sampling for the quantification of interstitial fluid using diffusion-weighted MRI, a genetic algorithm approach.
Magn Reson Med
July 2023
Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
Article Synopsis
- Multi-b-value diffusion-weighted MRI techniques can measure brain tissue properties but face challenges due to SNR and the selection of b-values for accurate data gathering.
- This study uses a genetic algorithm to determine the most effective b-values for estimating interstitial fluid in the brain, comparing its performance to other sampling methods.
- Results showed that the optimized b-value scheme significantly reduced the root mean square error (RMSE), improving the accuracy of the diffusion component estimation related to interstitial fluid.
Minimally invasive lobectomy versus stereotactic ablative radiotherapy for stage I non-small cell lung cancer.
Eur J Cardiothorac Surg
August 2022
Department of Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands.
Objectives: A minimally invasive lobectomy (MIL) is the standard treatment for stage I non-small cell lung cancer (NSCLC) in medically operable patients. Stereotactic ablative radiotherapy (SABR) is recommended for inoperable patients and has been proposed as a potential alternative for operable patients as well. Here, we present the results of a feasibility study in preparation for a nationwide retrospective cohort study, comparing outcomes between both treatment modalities.
View Article and Find Full Text PDFDiagnostic accuracy of Ara h 2 for detecting peanut allergy in children.
Clin Exp Allergy
August 2021
Department of Dermatology/Allergology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
Article Synopsis
- The study evaluated the effectiveness of a specific IgE test for diagnosing peanut allergies in children, aiming to reduce reliance on more invasive food challenge tests.
- It involved 150 children aged 3.5 to 18 in the Netherlands, comparing results from the IgE test with actual peanut ingestion to determine allergy status.
- The findings showed high diagnostic accuracy for the IgE test, identifying patients as peanut-tolerant or allergic, and potentially saving healthcare costs by using this method instead of national guidelines.
Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE).
Br J Anaesth
June 2021
Department of Anaesthesiology, Pharmacology, Intensive Care and Emergency Medicine, University Hospitals of Geneva, Geneva, Switzerland; University of Geneva, Geneva, Switzerland.
Background: Neonates and infants requiring anaesthesia are at risk of physiological instability and complications, but triggers for peri-anaesthetic interventions and associations with subsequent outcome are unknown.
Methods: This prospective, observational study recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries between March 2016 and January 2017. The primary aim was to identify thresholds of pre-determined physiological variables that triggered a medical intervention.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!