AI Article Synopsis
- Significant loss leads to high stress and poor well-being in humans, prompting researchers to create a rodent model that mimics this concept by taking away access to a rewarding environment.
- The study found that this loss caused behaviors and physiological changes similar to depression, such as feeling helpless, hormone imbalances, and overeating.
- Notably, these negative effects could be countered with antidepressant treatment, and were specifically linked to the removal of environmental enrichment rather than other factors like lack of exercise or social interaction.
Article Abstract
Significant loss produces the highest degree of stress and compromised well-being in humans. Current rodent models of stress involve the application of physically or psychologically aversive stimuli, but do not address the concept of loss. We developed a rodent model for significant loss, involving removal of long-term access to a rewarding enriched environment. Our results indicate that removal from environmental enrichment produces a profound behavioral and physiological phenotype with depression-like qualities, including helplessness behavior, hypothalamo-pituitary-adrenocortical axis dysregulation and overeating. Importantly, this enrichment removal phenotype was prevented by antidepressant treatment. Furthermore, the effects of enrichment removal do not occur following relief from chronic stress and are not duplicated by loss of exercise or social contact.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619656 | PMC |
| http://dx.doi.org/10.1016/j.psyneuen.2016.11.040 | DOI Listing |
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