AI Article Synopsis
- This study investigates how naringin can protect the brain following early brain injury due to subarachnoid hemorrhage (SAH).
- Naringin was tested on rats using specific doses to assess its effects on brain damage indicators like neurological function, swelling, and blood-brain barrier health.
- The findings revealed that naringin improved brain injury outcomes by reducing oxidative stress and cell death linked to SAH, highlighting its potential as a treatment for brain protection.
Article Abstract
This study aims to clarify the neuroprotective effect of naringin on early brain injury (EBI) following subarachnoid hemorrhage (SAH) and the possible mechanisms of naringin in the treatment of SAH. The endovascular puncture model was performed to induce SAH model in rats and the efficacy of 40mg/kg and 80mg/kg naringin were tested by intraperitoneally administration. SAH grade, neurological score, brain edema, blood-brain barrier permeability, the changes of oxidative stress related factors, apoptosis-related proteins, mitogen-activated protein kinase (MAPK) signaling pathway and neuronal morphology were detected to analyze the potential effect of naringin against SAH. The results demonstrated that naringin significantly ameliorated EBI, including SAH severity, neurologic deficits, brain edema and blood-brain barrier integrity by attenuating SAH-induced oxidative stress and apoptosis, and reduced the oxidant damage and apoptosis by inhibiting the activation of MAPK signaling pathway, which suggested a therapeutic potential of naringin in providing neuroprotection after SAH.
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| http://dx.doi.org/10.1016/j.brainresbull.2016.12.008 | DOI Listing |
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