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Baclofen-induced manic symptoms: case report and systematic review.
Psychosomatics
August 2016
The University of Lille Nord de France, F-59000 Lille, France; Department of Psychiatry, Centre Hospitalier Universitaire de Lille (CHRU), F-59037 Lille, France; INSERM, UMR-S1144, VariaPsy, Equipe 1, 75010, Paris, France; Department of Pharmacology, EA 1046, Univ Lille Nord de France, F-59000 Lille, France(MA, SD, RB, BR).
Background: The gamma-aminobutyric acid type B receptor agonist baclofen is approved for spasticity and is used off-label for diverse types of addictive disorders, notably alcohol dependence. Baclofen may induce numerous neuropsychiatric adverse drug reactions, including behavioral disinhibition. However, this precise adverse drug reaction has never been assessed using either a validated causality algorithm or a scale for manic symptoms.
View Article and Find Full Text PDFBaclofen-induced psychosis: two cases and a review.
J Clin Psychiatry
August 1988
Douglas Hospital Centre, Verdun, Quebec, Canada.
The authors describe two patients who were being treated with baclofen for tardive dyskinesia. One patient developed withdrawal symptoms after baclofen was stopped, and the other developed a manic attach while receiving the drug. The authors review the literature concerning these side effects and explore the possible mechanisms responsible for these effects.
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