Amphiphilic carbon dots for sensitive detection, intracellular imaging of Al.

Anal Chim Acta

State Key Laboratory of Separation Membranes and Membrane Processes, School of Environmental and Chemical Engineering, Tianjin Polytechnic University, Tianjin 300387, PR China. Electronic address:

Published: February 2017

In this paper, a simple and effective method was designed to synthesize hydrophobic carbon dots. Subsequently, amphiphilic fluorescent carbon dots (A-CDs) were synthesized by further surface modification. The result A-CDs show excellent optical properties with a quantum yield of 16.9%. It was interestingly found that morin (MR) and its fluorescent metal-ion complex (MR-Al) can successfully coordinate on the surface of A-CDs, the emission of A-CDs completely overlapped the absorption peak of MR-Al. Thus, the prepared A-CDs can be used as an effective fluorescent probe for Al based on a fluorescence resonance energy transfer process. The sensing platform can realize real-time detection of Al within 0.5 min. The fluorescence signals of the system were linearly correlated with the concentration of Al over a range of 8-20 μM, with a detection limit of 0.113 μM. The method was also successfully applied to image the distribution of Al in Human Umbilical Vein Endothelial Cells.

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Source
http://dx.doi.org/10.1016/j.aca.2016.11.049DOI Listing

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