AI Article Synopsis
- Angiogenin (ANG) is a ribonuclease that promotes blood vessel formation, but its detailed molecular mechanisms are not fully understood.
- ANG's ribonuclease activity is important for various biological processes, particularly in cleaving RNA, with mature tRNA identified as a specific target.
- The role of ANG in generating non-coding RNAs and its impact on rRNA transcription highlight the need for further research into its functions and RNA interactions.
Article Abstract
Angiogenin (ANG) is a secreted ribonuclease best known for its ability to promote formation of blood vessels. Extensive research over many years has elucidated its structure and biophysical properties, although our knowledge of molecular mechanisms underlying ANG-associated biologic processes remains limited. Intriguingly, many of processes require the ribonuclease activity of ANG, thus highlighting the importance of identifying and characterizing RNA targets and intermediates of ANG-mediated endonucleolytic cleavage. While ANG demonstrates ribonuclease activity toward many RNA substrates in vitro, specific target of ANG, namely mature tRNA, was only recently identified in vivo. ANG-mediated tRNA cleavage is an unorthodox manner of generating non-coding RNAs with diverse biologic activities. In addition, the ribonuclease activity of ANG has been reported to be crucial for rRNA transcription. Here we critically discuss various aspects of ANG biology related to its RNase activity and discuss areas in need of further investigation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324756 | PMC |
| http://dx.doi.org/10.1080/15476286.2016.1272746 | DOI Listing |
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