AI Article Synopsis
- The first efficient enantioselective α-amination of 2-substituted 3-indolinones has been developed using hydroquinidine as a chiral catalyst through an aza-Michael reaction.
- This method produces α-hydrazino esters in high yields and with significant enantiomeric excess.
- The process successfully creates a quaternary stereocenter and works well with a variety of substrates.
Article Abstract
An efficient enantioselective α-amination of 2-substituted 3-indolinones has been achieved for the first time using hydroquinidine as a chiral catalyst through an aza-Michael reaction. The desired α-hydrazino esters are obtained in excellent yields with high enantiomeric excess leading to a quaternary stereocenter with a broad substrate scope.
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| http://dx.doi.org/10.1021/acs.orglett.6b03473 | DOI Listing |
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