In this issue of , Aljitawi et al demonstrate for the first time that erythropoietin (EPO) signaling directly inhibits hematopoietic stem and progenitor cell (HSPC) migration and that an acute and transient reduction in peripheral EPO levels, via hyperbaric oxygen (HBO) therapy just before transplant, is safe and can enhance hematopoietic engraftment in patients undergoing umbilical cord blood transplantation (UCBT).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179340PMC
http://dx.doi.org/10.1182/blood-2016-11-748202DOI Listing

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