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Howell-Jolly Body-Like Neutrophil Inclusions Following Hematopoietic Stem Cell Transplantation: A Case Report.
Am J Case Rep
December 2024
Department of Clinical Laboratory, Aerospace Center Hospital, Beijing, China.
BACKGROUND In several studies, the presence of Howell-Jolly body-like inclusions within neutrophils has been observed in cases of HIV infection, SARS-CoV-2 infection, post-transplant immunosuppression, and during chemotherapy or antiviral therapy. The phenomenon of neutrophils exhibiting Howell-Jolly body-like inclusions on peripheral blood smears can be attributable to viral infections or the pharmacological effects of medications. CASE REPORT A 14-year-old male patient who had received a diagnosis of lymphoblastic leukemia a year ago underwent hematopoietic stem cell transplantation and was readmitted due to a recurrence of gastrointestinal graft-versus-host disease (GVHD).
View Article and Find Full Text PDFAssessing the accuracy and clinical utility of GPT-4O in abnormal blood cell morphology recognition.
Digit Health
November 2024
Department of Clinical Laboratory Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
Article Synopsis
- The study evaluated GPT-4O's ability to recognize abnormal blood cell morphology, an important aspect of hematologic diagnosis, and compared its performance to experienced hematologists.
- GPT-4O showed a 70% accuracy rate, which was significantly lower than the 95.42% accuracy of hematologists, highlighting its limitations in clinical effectiveness.
- While GPT-4O did well with some specific cell types, overall, it struggled with critical recognition tasks and requires improvements in its algorithms and dataset for reliable clinical application in the future.*
A rare glimpse of Fessas bodies in a patient with β-thalassemia major postsplenectomy.
Blood
October 2024
Fraser Health Authority.
MDS-Type Morphologic Abnormalities of Peripheral Blood Granulocytes in Symptomatic COVID-19 Patients.
Int J Hematol Oncol Stem Cell Res
July 2024
Division of Laboratory Hematology and Blood Banking, Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Hematological abnormalities in COVID-19 infection included quantitative and qualitative changes and should be further characterized. Evaluation for myelodysplastic syndromes (MDS) is usually prompted by abnormal hematologic findings and the presence of dysplastic morphologies. Viral infections are considered to be the cause of dysplastic morphologies and should be considered by morphologists.
View Article and Find Full Text PDFEvaluating the Effectiveness of Laparoscopic Removal of an Accessory Spleen After a Failed Splenectomy for Immune Thrombocytopenia.
Cureus
July 2024
Surgery, BronxCare Health System, New York, USA.
Immune thrombocytopenic purpura (ITP) is a challenging condition to manage especially when conventional treatment methods, including splenectomy, fail. This report evaluates the effectiveness of laparoscopic removal of accessory spleen for chronic refractory ITP after an initial splenectomy. A 73-year-old African American male with a history of ITP, previously treated with laparoscopic splenectomy nine years ago, presented with severe thrombocytopenia that was found to be refractory to medical therapies.
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