Epistasis is a key concept in the theory of adaptation. Indicators of epistasis are of interest for large systems where systematic fitness measurements may not be possible. Some recent approaches depend on information theory. We show that considering shared entropy for pairs of loci can be misleading. The reason is that shared entropy does not imply epistasis for the pair. This observation holds true also in the absence of higher order epistasis. We discuss a method for reducing the number of false positives. However, our main conclusion is that entropy-based approaches have serious limitations in this context.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178987 | PMC |
| http://dx.doi.org/10.1371/journal.pgen.1006322 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
rsfMRI-based brain entropy is negatively correlated with gray matter volume and surface area.
Brain Struct Funct
January 2025
Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, 670 W Baltimore St, HSF III, R1173, Baltimore, MD, 21202, USA.
The brain entropy (BEN) reflects the randomness of brain activity and is inversely related to its temporal coherence. In recent years, BEN has been found to be associated with a number of neurocognitive, biological, and sociodemographic variables such as fluid intelligence, age, sex, and education. However, evidence regarding the potential relationship between BEN and brain structure is still lacking.
View Article and Find Full Text PDFImportance: The pathophysiology of ADHD is complicated by high rates of psychiatric comorbidities, thus delineating unique versus shared functional brain perturbations is critical in elucidating illness pathophysiology.
Objective: To investigate resting-state fMRI (rsfMRI)-complexity alterations among children with ADHD, oppositional defiant disorder (ODD), and obsessive-compulsive disorder (OCD), respectively, and comorbid ADHD, ODD, and OCD, within the cool and hot executive function (EF) networks.
Design: We leveraged baseline data (wave 0) from the Adolescent Brain and Cognitive Development (ABCD) Study.
Is sharing always caring? Entropy, boundaries and the plurality of psychotherapeutic process.
Phys Life Rev
January 2025
CHU Sainte-Justine Azrieli Research Center, Department of Psychiatry, Université de Montréal, Montréal, Quebec, Canada; Division of Social and Transcultural Psychiatry, McGill University, Montréal, Quebec, Canada; Mila - Quebec AI Institute, Université de Montréal, Montréal, Quebec, Canada. Electronic address:
Discontinuous Structural Transitions in Fluids with Competing Interactions.
Entropy (Basel)
January 2025
Instituto de Energías Renovables, Universidad Nacional Autónoma de México (UNAM), Temixco 62580, Mexico.
This paper explores how competing interactions in the intermolecular potential of fluids affect their structural transitions. This study employs a versatile potential model with a hard core followed by two constant steps, representing wells or shoulders, analyzed in both one-dimensional (1D) and three-dimensional (3D) systems. Comparing these dimensionalities highlights the effect of confinement on structural transitions.
View Article and Find Full Text PDFEnvironmental Performance, Financial Constraints, and Tax Avoidance Practices: Insights from FTSE All-Share Companies.
Entropy (Basel)
January 2025
School of Business, University of Leicester, Leicester LE2 1RQ, UK.
Through its initiative known as the Climate Change Act (2008), the Government of the United Kingdom encourages corporations to enhance their environmental performance with the significant aim of reducing targeted greenhouse gas emissions by the year 2050. Previous research has predominantly assessed this encouragement favourably, suggesting that improved environmental performance bolsters governmental efforts to protect the environment and fosters commendable corporate governance practices among companies. Studies indicate that organisations exhibiting strong corporate social responsibility (CSR), environmental, social, and governance (ESG) criteria, or high levels of environmental performance often engage in lower occurrences of tax avoidance.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!