AI Article Synopsis
- Researchers found that the anterior olfactory nucleus pars medialis (mAON) in the brain actively influences how we perceive smells and behave based on those smells.
- They discovered that the mAON can increase or decrease our sensitivity to odors, showing a complex relationship between smell and behavior.
- By using optogenetic stimulation, they were able to demonstrate that signals from the ventral hippocampus can effectively change how this mAON region functions, impacting behavior related to olfaction.
Article Abstract
Olfactory processing is thought to be actively modulated by the top-down input from cortical regions, but the behavioural function of these signals remains unclear. Here we find that cortical feedback from the anterior olfactory nucleus pars medialis (mAON) bidirectionally modulates olfactory sensitivity and olfaction-dependent behaviours. To identify a limbic input that tunes this mAON switch, we further demonstrate that optogenetic stimulation of ventral hippocampal inputs to the mAON is sufficient to alter olfaction-dependent behaviours.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192165 | PMC |
| http://dx.doi.org/10.1038/ncomms13721 | DOI Listing |
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