This study presents the synthesis and UV-Vis characterization of Cu nanocomposites from ethylenediamine (EDA) (E), diethylenetriamine (DETA) (D), and Jeffamine® T-403 (P) cored PAMAM dendrimers (PAMAMs) with TRIS and carboxyl surface functional groups. Cu-PAMAM dendrimer encapsulated nanoparticles (Cu-DENs) were characterized by UV-Vis spectroscopy. Disappearance of the 680 nm d-d transition and 270-300 nm ligand to metal charge transfer (LMCT) peaks and the formation of monotically increasing exponential band were used as the evidence of the successful synthesis of Cu-DENs in addition to immediate color change of dendrimer-metal mixture solutions from blue to golden brown by reduction. Synthesized Cu-DENs could be facilitated as novel alternatives to the existing nanomaterials used in a wide range of applications involving bio and chemical sensors, catalysis, hydrogenations, oxidations, semiconductors, noble metals, magnetic dendrimer nanocomposites, environmental cleanup and many others.
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http://dx.doi.org/10.17344/acsi.2016.2528 | DOI Listing |
Chemistry
November 2024
Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Liquid-crystallization-driven self-assembly (LCDSA) has recently emerged as an efficient strategy to create uniform one-dimensional (1-D), 2-D and 3-D nanostructures in a controlled manner. However, the examples of generation of uniform multi-morphology nanostructures from solution self-assembly of one single polymer sample are rare. Herein, we report the first example of preparation of multi-morphology fried-egg-like nanostructures consisting of an inner spherical/bowl-like core of uniform size and platelets protruded from the core by LCDSA of PAMAM-Azo (PAMAM=polyamidoamine, Azo=azobenzene) in methanol.
View Article and Find Full Text PDFTalanta
January 2025
Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China.
PD-L1 positive tumor derived exosomes (TEXs) play a significant role in disease progression, tumor metastasis and cancer immunotherapy. However, the overlap of PD-L1 between TEXs and non-tumor derived exosomes (non-TEXs) restricts the specific isolation and quantification of TEX from clinical samples. Herein, a new aptamer-functionalized and hydrophilic immunomagnetic substrate was designed by decorating generation 5 polyamidoamine dendrimers (G5 PAMAM), zwitterionic trimethylamine N-oxide (TMAO) and EpCAM (Epithelial cell adhesion molecule) aptamers on magnetic cores sequentially (FeO@PAMAM@TMAO@Aptamer, named as FPTA) for rapid target and efficient capture of TEXs.
View Article and Find Full Text PDFMacromol Rapid Commun
September 2024
Medical Science and Technology Innovation Center, Shandong First Medical University, Jinan, Shandong, 250117, P. R. China.
Core-shell tecto dendrimers (CSTDs) with excellent physicochemical properties and good tumor penetration and gene transfection efficiency have been demonstrated to have the potential to replace high-generation dendrimers in biomedical applications. However, their characterization and related biological properties of CSTDs for enhanced tumor penetration and gene delivery still lack in-depth investigation. Herein, three types of dual-responsive CSTDs are designed for thorough physicochemical characterization and investigation of their tumor penetration and gene delivery efficiency.
View Article and Find Full Text PDFBiomater Sci
April 2024
MOE Key Laboratory of High Performance Polymer Materials and Technology, State Key Laboratory of Analytical Chemistry for Life Science, and College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210093, P.R. China.
Tumor penetration is a critical determinant of the therapy efficacy of nanomedicines. However, the dense extracellular matrix (ECM) in tumors significantly hampers the deep penetration of nanomedicines, resulting in large drug-untouchable areas and unsatisfactory therapy efficacy. Herein, we synthesized a third-generation PAMAM-cored multiarm copolymer and modified the polymer with collagenase to enhance its tumor penetration.
View Article and Find Full Text PDFACS Appl Bio Mater
June 2023
Department of Polymer Science & Engineering, State Key Laboratory of Analytical Chemistry for Life Science, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China.
Size is one of the crucial factors influencing the biological properties of nanomedicines. However, the size control of nanomaterials is still very challenging, and the size effect on their biological properties is worth studying. Herein, we present the synthesis and size control of a series of multiarm block copolymers with the third-generation PAMAM (G3 PAMAM) as the core.
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