In the latest decades, an important change has been registered in liver surgery related to the progress of surgical techniques, critical care, and postoperative treatment, allowing a sharp decrease in mortality and morbidity. However, management of post-hepatectomy liver failure (PHLF) still remains a challenge and no supportive treatment has been found to be generally effective. The present study is a reappraisal of plasmapheresis as a potential supportive measure in patients with PHLF following major liver resection.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161501 | PMC |
| http://dx.doi.org/10.7759/cureus.884 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Minimum proportion of future liver remnant in safe major hepatopancreatoduodenectomy.
Ann Gastroenterol Surg
January 2025
Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery Shinshu University School of Medicine Matsumoto Japan.
Background And Aim: Post-hepatectomy liver failure (PHLF) after major hepatopancreatoduodenectomy (HPD) is a challenge to overcome. However, the appropriate target proportion of the future liver remnant (pFLR) to prevent severe PHLF in major HPD remains uncertain. This study aimed to determine the minimum pFLR required for safe major HPD.
View Article and Find Full Text PDFTextbook outcome in liver surgery for intrahepatic cholangiocarcinoma: defining predictors of an optimal postoperative course using machine learning.
HPB (Oxford)
December 2024
Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, OH, USA. Electronic address:
Background: We sought to define textbook outcome in liver surgery (TOLS) for intrahepatic cholangiocarcinoma (ICC) by considering the implications of perioperative outcomes on overall survival (OS).
Methods: Using a multi-institutional database, TOLS for ICC was defined by employing novel machine learning (ML) models to identify perioperative factors most strongly predictive of OS ≥ 12 months. Subsequently, clinicopathologic factors associated with achieving TOLS were investigated.
Machine learning based prediction model for bile leak following hepatectomy for liver cancer.
HPB (Oxford)
December 2024
Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, OH, United States. Electronic address:
Objective: We sought to develop a machine learning (ML) preoperative model to predict bile leak following hepatectomy for primary and secondary liver cancer.
Methods: An eXtreme Gradient Boosting (XGBoost) model was developed to predict post-hepatectomy bile leak using data from the ACS-NSQIP database. The model was externally validated using data from hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) multi-institutional databases.
Diacylglycerol kinase alpha regulates post-hepatectomy liver regeneration.
Sci Rep
January 2025
Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, N15 W7 Kita-Ku, Sapporo, Hokkaido, 060-8638, Japan.
Article Synopsis
- Diacylglycerol kinases (DGKs), specifically DGKα, are important in liver regeneration and tumor progression but their role in liver regeneration has been unclear.
- Research using DGKα knockout mice after a 70% liver removal showed these mice had worse outcomes, including higher enzyme levels, jaundice, and a death rate of around 40%.
- DGKα KO mice also showed impaired liver function, low energy levels, and reduced cell proliferation, highlighting DGKα’s crucial role in liver regeneration and suggesting it could be a target for therapy.
NLRP3 inflammasome constrains liver regeneration through impairing MerTK-mediated macrophage efferocytosis.
Sci Adv
January 2025
School of Basic Medicine, Qingdao University, 308 Ningxia Road, Qingdao 266071, China.
Article Synopsis
- The NLRP3 inflammasome is important in liver diseases, but its specific function in liver regeneration is not well understood.
- In a study with mice undergoing partial hepatectomy, it was found that inhibiting or removing NLRP3 improved liver regeneration, while increasing its levels hindered recovery.
- The benefits of NLRP3 depletion are linked to the activation of certain macrophages, and using drugs to inhibit NLRP3 showed promise in improving liver regeneration, especially in mice on a high-fat diet.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!