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Trimetazidine an emerging paradigm in renal therapeutics: Preclinical and clinical insights.
Eur J Pharmacol
December 2021
Chitkara College of Pharmacy, Chitkara University, Punjab, India. Electronic address:
Trimetazidine (TMZ) is a well-known anti-ischemic agent used for the treatment of angina pectoris. In the past decades, the efficacy of this drug has been tested in a wide range of kidney injuries, including drug-induced nephrotoxicity (DIN), radio-contrast agent-induced nephropathy, and surgically induced renal ischemic injury. TMZhas renoprotective effects by attenuating oxidative stress, inflammatory cytokine release, maintaining oxygen and energy balance.
View Article and Find Full Text PDF[Anti-ischemic protection of the liver using perfluorocarbon emulsion].
Gematol Transfuziol
January 1989
Anti-ischemic effectiveness of a Soviet perfluorocarbon emulsion (PFE) was studied in 43 experiments on rabbits with 90-min constriction of the hepatoduodenal ligament and under hypothermic perfusion of the liver during ischemia in the open contour. It has been established that PFE perfusion to a great extent promotes the retention of the ischemized liver function.
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