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http://dx.doi.org/10.1155/2016/9028409 | DOI Listing |
Background: The use of liquid biopsy of total cell-free DNA (cfDNA) to identify otherwise undetectable cancers has attracted interest; however, its efficacy remains unknown. We explored whether analysis using total cfDNA is efficacious for Japanese patients with oral squamous cell carcinoma (OSCC).
Methods: We collected total cfDNA from nine patients with OSCC preoperatively, 1 month postoperatively, and every 3 months thereafter to analyze this association.
BMC Bioinformatics
December 2024
School of Computer Engineering, Jiangsu Ocean University, Lianyungang, 222005, China.
Background: Cancer classification has consistently been a challenging problem, with the main difficulties being high-dimensional data and the collection of patient samples. Concretely, obtaining patient samples is a costly and resource-intensive process, and imbalances often exist between samples. Moreover, expression data is characterized by high dimensionality, small samples and high noise, which could easily lead to struggles such as dimensionality catastrophe and overfitting.
View Article and Find Full Text PDFBMC Genomics
December 2024
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, 02-106, Poland.
Low Complexity Regions (LCRs) are segments of proteins with a low diversity of amino acid composition. These regions play important roles in proteins. However, annotations describing these functions are dispersed across databases and scientific literature.
View Article and Find Full Text PDFBMC Genomics
December 2024
School of Information Engineering, Jingdezhen Ceramic University, Jingdezhen, 333403, China.
Background: The subcellular localization of mRNA plays a crucial role in gene expression regulation and various cellular processes. However, existing wet lab techniques like RNA-FISH are usually time-consuming, labor-intensive, and limited to specific tissue types. Researchers have developed several computational methods to predict mRNA subcellular localization to address this.
View Article and Find Full Text PDFMol Med
December 2024
Disease Prevention and Health Management Center, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310006, Zhejiang, China.
Background: Nonalcoholic fatty liver disease (NAFLD) has developed as a leading public wellness challenge as a result of changes in dietary patterns. Unfortunately, there is still a lack of effective pharmacotherapy methods for NAFLD. Wang's empirical formula (WSF) has demonstrated considerable clinical efficacy in treating metabolic disorders for years.
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