AI Article Synopsis
- Directional fluid flow is crucial for the development of embryos and the maintenance of bodily organs.
- The review focuses on different types of organ-blood barriers (specifically kidney, eye, and brain) and explores how various forces and mechanisms control fluid movement across these barriers.
- It also highlights the importance of communication between different cell types, like barrier epithelial cells and perivascular cells, in establishing and preserving the integrity of organ-blood barriers.
Article Abstract
Directional fluid flow is an essential process for embryo development as well as for organ and organism homeostasis. Here, we review the diverse structure of various organ-blood barriers, the driving forces, transporters, and polarity mechanisms that regulate fluid transport across them, focusing on kidney-, eye-, and brain-blood barriers. We end by discussing how cross talk between barrier epithelial and endothelial cells, perivascular cells, and basement membrane signaling contribute to generate and maintain organ-blood barriers.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334253 | PMC |
| http://dx.doi.org/10.1101/cshperspect.a027847 | DOI Listing |
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