The authors presented clinical and x-ray findings of combined investigation of 94 patients with chronic bronchitis. X-ray symptoms of disturbed bronchial permeability (DBP) in this pathology were studied. Bronchograms, bronchosonograms performed in different phases of respiration using broncholytic drugs, video tape recording, coherent-optic processing of bronchograms, and a method of digital processing of bronchograms proposed by the authors were employed. The importance of x-ray examination in the diagnosis of DBP was shown. The classification, nature, site and spreading of DBP were described. X-ray findings were compared with clinical and laboratory findings.
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Respir Res
December 2024
PRéTi, Université de Poitiers, Poitiers, France.
Background: Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) channel. For people with CF (pwCF) affected by the most common pathogenic variant F508del, a tritherapy, named Trikafta/Kaftrio (ETI: elexacaftor (VX-445) /tezacaftor (VX-661) / ivacaftor (VX-770)) was successfully developed. However, in CF airway epithelial cells the calcium homeostasis is also disturbed; it is observed an increased calcium mobilization in CF cells compared to non-CF cells.
View Article and Find Full Text PDFNutrients
November 2024
Center of Immuno-Physiology and Biotechnologies, Department of Functional Sciences, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Background: A growing body of evidence links a high-fructose diet (HFrD) to metabolic disturbances, including inflammation, dyslipidemia, insulin resistance and also endothelial dysfunction, yet its role in allergic asthma remains underexplored. Considering that obesity and hypercholesterolemia exacerbate asthma by promoting systemic inflammation, investigating interventions with dual metabolic and anti-inflammatory effects is essential. This study aimed to evaluate the potential modulatory effects of rosuvastatin in ameliorating the effects of HFrD-induced metabolic and vascular dysfunction in the context of allergic asthma.
View Article and Find Full Text PDFMed J Islam Repub Iran
August 2024
Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Mansoura University, Egypt.
Background: Pectus excavatum is the most frequent congenital defect of the chest wall. Surgical treatment with modified Ravitch-type repair is recommended in patients with cosmetic dissatisfaction or considerable cardiopulmonary symptoms. We aimed to analyze the surgical, aesthetic, cardiopulmonary functions and patient satisfaction outcomes of modified Ravitch repair pre and postoperatively.
View Article and Find Full Text PDFDokl Biochem Biophys
December 2024
Far Eastern Scientific Center of Physiology and Pathology of Respiration, Blagoveshchensk, Russia.
Introduction: It is known that monocytes can make a significant contribution to the development of chronic obstructive pulmonary disease (COPD); however, the features of the transcriptome of these cells associated with the disease remain poorly understood.
Aim: The aim of the study was to perform monocyte transcriptome analysis for identification of differentially expressed genes and key disturbances in biological processes in these cells in COPD.
Materials And Methods: The study included three COPD patients and three smokers without bronchial obstruction.
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