AI Article Synopsis
- - The study examined plasma levels of the chemokines CCL3 and CCL4 in patients with different clinical forms of chronic Chagas disease, focusing on those with and without left ventricular systolic dysfunction (LVSD).
- - It involved analyzing plasma samples from 75 patients using ELISA and Milliplex® MAP assay, confirming the T. cruzi infection.
- - Results showed no significant level differences of CCL3 and CCL4 between digestive and cardiac forms of Chagas disease, and found that while LVSD patients had higher chemokine levels, CCL3 and CCL4 do not seem to affect susceptibility to the disease forms or influence LVSD development.
Article Abstract
The aim of this study was to investigate the plasma levels of the CCL3 and CCL4 chemokines in patients with the cardiac and digestive clinical forms of chronic Chagas disease and in cardiac patients with and without left ventricular systolic dysfunction (LVSD). Plasma samples from 75 patients were evaluated by enzyme-linked immunosorbent assay (ELISA) to confirm infection by T. cruzi. Plasma levels of the CCL3 and CCL4 chemokines were measured using Milliplex® MAP assay (Millipore). There were no significant differences in the levels of CCL3 and CCL4 between patients with the digestive and cardiac clinical forms of Chagas disease. Moreover, no significant differences were found between patients without LVSD and those with LVSD. Higher CCL3 and CCL4 plasma levels were found in patients with LVSD compared to those with the digestive form of the disease. The CCL3 and CCL4 chemokines might not be involved in differential susceptibility to the digestive and cardiac clinical forms of chronic Chagas disease, and it seems they do not influence the development of LVSD.
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| http://dx.doi.org/10.1016/j.cyto.2016.12.002 | DOI Listing |
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