AI Article Synopsis
- This commentary examines the roles of Fibroblast Growth Factors (FGFs) in limb development and the conflicting findings regarding their function, particularly in relation to the Apical Ectodermal Ridge (AER).
- It highlights the differing effects of surgical versus genetic removal of AER-FGFs on cell death patterns, indicating an unresolved conflict in the research.
- The authors propose that AER signaling might involve additional components and emphasize the importance of non-AER ectoderm signals, calling for new experiments utilizing innovative technologies to clarify these interactions.
Article Abstract
In this commentary we focus on the function of FGFs during limb development and morphogenesis. Our goal is to understand, interpret and, when possible, reconcile the interesting findings and conflicting results that remain unexplained. For example, the cell death pattern observed after surgical removal of the AER versus genetic removal of the AER-Fgfs is strikingly different and the field is at an impasse with regard to an explanation. We also discuss the idea that AER function may involve signaling components in addition to the AER-FGFs and that signaling from the non-AER ectoderm may also have a significant contribution. We hope that a re-evaluation of current studies and a discussion of outstanding questions will motivate new experiments, especially considering the availability of new technologies, that will fuel further progress toward understanding the intricate ectoderm-to-mesoderm crosstalk during limb development. Developmental Dynamics 246:208-216, 2017. © 2016 Wiley Periodicals, Inc.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262604 | PMC |
| http://dx.doi.org/10.1002/dvdy.24480 | DOI Listing |
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