AI Article Synopsis
- The study investigated the relationship between progranulin levels and metabolic syndrome in type 2 diabetic patients compared to healthy controls.
- Participants with metabolic syndrome exhibited higher triglycerides, waist circumference, and blood pressure, while having lower HDL-cholesterol levels than those without metabolic syndrome and healthy individuals.
- Although serum progranulin levels were slightly elevated in those with metabolic syndrome, no significant correlation was found with the components of metabolic syndrome, suggesting that progranulin's role in managing type 2 diabetes may warrant further research.
Article Abstract
Introduction: The role of progranulin in individuals with metabolic syndrome is not exactly clear.We aimed to assess the serum level of progranulin in type 2 diabetic patients with and without metabolic syndrome and compare them with healthy controls.
Methods: The study included 60 patients with type 2 diabetes and 30 healthy individuals as control groups. Biochemical parameters and progranulin levels were determined.
Results: Subjects with metabolic syndrome showed significantly higher levels of triglyceride, waist circumference, BMI, systolic and diastolic blood pressure than subjects without metabolic syndrome and the control groups, while HDL-cholesterol level was significantly lower in subjects with metabolic syndrome. Fasting blood sugar was significantly higher in type 2 diabetic patients than in the control groups. Serum level of progranulin was slightly increased in subjects with metabolic syndrome. Serum progranulin level had no significant relationship with metabolic syndrome components.
Conclusions: Serum progranulin was also not dependent on cardiometabolic risk factors for subjects with metabolic syndrome, but it could be considered for the management of type 2 diabetes mellitus. Further studies are recommended to explain the effect of progranulin on the pathogenesis of metabolic risk factors.
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| http://dx.doi.org/10.1515/rjim-2016-0034 | DOI Listing |
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