AI Article Synopsis
- The study examined the relationship between specific IL-10 gene polymorphisms and the regression of periportal fibrosis after treatment for schistosomiasis in Brazilian patients.
- The research included 125 patients who were monitored over a two-year period following treatment for Schistosoma mansoni.
- Findings indicated no significant association between IL-10 polymorphisms and the improvement of periportal fibrosis in the studied population.
Article Abstract
Introduction:: We evaluated the associations between interleukin-10 (IL-10) gene polymorphisms -G1082A/-C819T/-C592A and periportal fibrosis regression after specific treatment for schistosomiasis.
Methods:: This retrospective cohort study involved 125 Brazilian patients infected with Schistosomiasis mansoni, who were followed up for 2 years after specific treatment to estimate the probability of periportal fibrosis regression.
Results:: There was no evidence of associations between IL-10 polymorphisms and periportal fibrosis regression after treatment.
Conclusions:: There was no evidence of associations between gene promoter polymorphisms of IL-10 and the regression of periportal fibrosis in this Brazilian population.
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| http://dx.doi.org/10.1590/0037-8682-0141-2016 | DOI Listing |
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