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Synthetic data-driven overlapped neural spikes sorting: decomposing hidden spikes from overlapping spikes.
Mol Brain
November 2024
Translational Brain Research Center, Catholic Kwandong University, Gangneung, Republic of Korea.
Article Synopsis
- Sorting spikes from extracellular recordings is crucial for understanding neural coding, but identifying overlapping spikes remains challenging due to the complexity of neuronal activity.
- This study introduces a novel method for detecting and decomposing overlapping spikes using estimated spike templates and a particle swarm optimization technique, leading to improved identification accuracy.
- Results show the proposed approach can effectively classify overlapping spikes, achieving a high F1 score, and also infer the synchronization of hidden spikes, enhancing tools for neural activity analysis.
The fuzzy system ensembles entomological, epidemiological, demographic and environmental data to unravel the dengue transmission risk in an endemic city.
BMC Public Health
September 2024
Laboratório de Mosquitos Transmissores de Hematozoários, Instituto Oswaldo Cruz, Fiocruz - IOC, Rio de Janeiro, RJ, Brazil.
Background: The effectiveness of dengue control interventions depends on an effective integrated surveillance system that involves analysis of multiple variables associated with the natural history and transmission dynamics of this arbovirus. Entomological indicators associated with other biotic and abiotic parameters can assertively characterize the spatiotemporal trends related to dengue transmission risk. However, the unpredictability of the non-linear nature of the data, as well as the uncertainty and subjectivity inherent in biological data are often neglected in conventional models.
View Article and Find Full Text PDF[Translated article] Truths and myths about augmentation techniques in the treatment of fragility fractures.
Rev Esp Cir Ortop Traumatol
August 2024
Unidad de Columna, Servicio de Cirugía Ortopédica y Traumatología, Hospital Clínico Universitario de Valladolid, Valladolid, Spain. Electronic address:
The main event of osteoporosis is fragility fractures. Vertebral compression fractures are the most commonly fragility fracture related to osteoporosis. Our goal is to review the available literature to confirm or deny concepts learned about spinal cementation and adapt our clinical practice according to scientific evidence.
View Article and Find Full Text PDFUnraveling anti-aging mystery of green tea in C. elegans: Chemical truth and multiple mechanisms.
Food Chem
December 2024
Natural Products Laboratory, International Joint Laboratory of Tea Chemistry and Health Effects, State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, People's Republic of China; Joint Research Center for Food Nutrition and Health of IHM, Hefei, China. Electronic address:
Tea drinking impacts aging and aging-related diseases. However, knowledge of anti-aging molecules other than the major catechins in complex tea extracts remains limited. Here we used Caenorhabditis elegans to analyze the longevity effects of tea extracts and constituents comprehensively.
View Article and Find Full Text PDFA journey in unraveling the enantiorecognition mechanism of 3,5-dinitrobenzoyl-amino acids with two Cinchona alkaloid-based chiral stationary phases: The power of molecular dynamic simulations.
Anal Chim Acta
July 2024
Department of Pharmaceutical Sciences, University of Perugia, Via Fabretti 48, 06123, Perugia, Italy. Electronic address:
Background: Innovations in computer hardware and software capabilities have paved the way for advances in molecular modelling techniques and methods, leading to an unprecedented expansion of their potential applications. In contrast to the docking technique, which usually identifies the most stable selector-selectand (SO-SA) complex for each enantiomer, the molecular dynamics (MD) technique enables the consideration of a distribution of the SO-SA complexes based on their energy profile. This approach provides a more truthful representation of the processes occurring within the column.
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