AI Article Synopsis
- Spillane and Tolar (2016) investigate how the surfaces of antigen-presenting cells impact the way B cells take up surface-bound antigens using advanced DNA nanosensors for cell imaging.
- They find that softer, more flexible surfaces enhance the mechanical forces that help B cells extract antigens, while stiffer surfaces lead to enzyme-driven release of antigens before B cells can internalize them.
- This research highlights the significance of physical surface properties in regulating immune responses and antigen uptake by B cells.
Article Abstract
Using an exquisite cell imaging approach based on DNA nanosensors, Spillane and Tolar (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607064) explore how the physical properties of antigen-presenting cell surfaces affect how B cells internalize surface-tethered antigens. Soft and flexible surfaces promote mechanical force-mediated antigen extraction, whereas stiff surfaces lead to enzyme-mediated antigen release before subsequent internalization.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223618 | PMC |
| http://dx.doi.org/10.1083/jcb.201612043 | DOI Listing |
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