Phagocytosis by professional and non-professional phagocytes plays a critical role in tissue homeostasis and the immune response. Using an airway inflammation model, Han et al. (2016) report in Nature that macrophages secrete IGF-1 to signal epithelial cells to stop ingesting apoptotic cells while increasing the uptake of anti-inflammatory macrophage-derived microvesicles.
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Macrophages Tell the Non-Professionals What to Do.
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INRS-Institut Armand-Frappier and Centre for Host-Parasite Interactions, Laval, QC H7V 1B7, Canada. Electronic address:
Phagocytosis by professional and non-professional phagocytes plays a critical role in tissue homeostasis and the immune response. Using an airway inflammation model, Han et al. (2016) report in Nature that macrophages secrete IGF-1 to signal epithelial cells to stop ingesting apoptotic cells while increasing the uptake of anti-inflammatory macrophage-derived microvesicles.
View Article and Find Full Text PDF[Contact allergies in musicians].
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IFOM - Institut für Forschung in der Operativen Medizin, Department für Humanmedizin, Universität Witten/Herdecke.
During the last years, the problem of allergic diseases has increased. Allergies are errant immune responses to a normally harmless substance. In musicians the allergic contact dermatitis to exotic woods is a special problem.
View Article and Find Full Text PDFDifferences between the clearance of apoptotic cells by professional and non-professional phagocytes.
Curr Biol
July 2000
Medical Research Council Laboratory for Molecular Cell Biology, Medical Research Council Developmental Neurobiology Programme, University College London, London, WC1E 6BT, UK.
Both professional and non-professional phagocytes [1] participate in clearing the massive numbers of cells that undergo apoptosis during animal development [2], but it is not known how they divide this task. Using time-lapse recordings of cells in culture, we show that professional phagocytes (brain macrophages or microglia) are highly motile, ingest apoptotic cells immediately, and digest them quickly. Non-professionals such as BHK and lens epithelial cells are sessile, often recognize apoptotic cells as soon as they die by showing characteristic palpating movements, but delay ingestion until several hours later.
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