AI Article Synopsis
- A new method called Pd-catalyzed asymmetric allylic alkylation (Pd-AAA) is introduced, which uses enol carbonates from γ-butyrolactones.
- This technique produces α,α'-disubstituted γ-butyrolactones with high yields and enantioselectivities, achieving up to 94% enantiomeric excess (ee).
- The method has also been successfully utilized to create chiral spirocyclic compounds.
Article Abstract
The Pd-catalyzed asymmetric allylic alkylation (Pd-AAA) of enol carbonates derived from γ-butyrolactones is reported, affording the corresponding enantioenriched α,α'-disubstituted γ-butyrolactones in both high yields and high enantioselectivities (up to 94% ee). This method was eventually applied to the synthesis of chiral spirocyclic compounds.
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| http://dx.doi.org/10.1021/acs.orglett.6b02971 | DOI Listing |
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