Hydrogen sulfide (HS) is a mediator of a number of cellular processes, and modulating cellular levels of this gas has emerged as an important therapeutic area. Localized generation of HS is thus very useful but highly challenging. Here, we report pivaloyloxymethyl-based carbonothioates and carbamothioates that are activated by the enzyme, esterase, to generate carbonyl sulfide (COS), which is hydrolyzed to HS.
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| http://dx.doi.org/10.1021/acs.orglett.6b03336 | DOI Listing |
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