A prospective study was undertaken to determine causes of death at Tshepong Hospital in the western Transvaal over 1 year. Specific attention was paid to the accurate coding of causes of death; this entailed discussions with the attending doctor as well as 38 autopsies. Only 2.4% of deaths were coded under 'symptoms, signs and ill-defined conditions'. The 1046 deaths followed a typical Third-World pattern when classified according to the International Classification of Diseases (1979). Deaths during the perinatal period were additionally classified according to the recommendations of the Third Conference on Priorities in Perinatal Care in South Africa. The commonest cause of death was conditions originating in the perinatal period (19.2%), followed by infections and parasitic diseases (15.9%), diseases of the circulatory system (14.8%), endocrine, nutritional and metabolic diseases and immune-disorders (12.1%), and neoplasms (8.8%). The other main groups accounted for under 8% each. The commonest cause of death in all age groups above 35 years was diseases of the cardiovascular system, and the commonest cause of death among females aged 15 - 35 years was complications of pregnancy, childbirth and the puerperium. The hospital maternal mortality rate was 4.7/1,000 deliveries and the hospital perinatal mortality rate was 53/1,000 deliveries.
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Discov Oncol
March 2025
Biotechnology Research and Innovation Council-National Institute of Biomedical Genomics, N.S.S., Kalyani, 741251, West Bengal, India.
MicroRNAs (miRNAs) are a class of small non-coding RNAs which are associated with post-transcriptional regulation of gene expression. Dysfunction or aberrant expression of miRNAs is predominant in various malignancies including lung cancer. Lung cancer is one of the commonest causes of cancer-related death worldwide, with a five-year survival of only 10-20%.
View Article and Find Full Text PDFBMC Public Health
March 2025
Uganda Sickle Cell Rescue Foundation, Kampala, Uganda.
Background: Sickle cell disease (SCD) is a debilitating hereditary medical condition associated with pain, stigma, morbidity, and early death. To reduce the prevalence and improve the quality of life of persons with SCD, improved knowledge, practices and reduced stigma are key for Uganda since improved medical breakthroughs in SCD diagnosis, care, and management are expensive in Uganda. However, there is limited research on knowledge, attitudes, and practice (KAP) towards SCD, therefore this study presents the levels and determinants of SCD KAP in Alebtong district, Lango region in Northern Uganda.
View Article and Find Full Text PDFInt J Emerg Med
March 2025
Department of Emergency Medicine, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore.
Aims: Emergency department (ED) revisits within 72 h is a standard quality measure for emergency care but most revisits are managed and discharged. However, a sub-group of revisits are due to clinical deterioration resulting in admissions to higher acuity care or even mortality. We aimed to identify these critical revisits and their associated risk factors.
View Article and Find Full Text PDFBMC Psychiatry
February 2025
Michael G. Degroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Background: Breast cancer is the most commonly diagnosed cancer and a leading cause of cancer-related deaths among women globally. The cases of breast cancer have continued to rise in Nigeria and surgery remains one of the commonest treatment modalities. However, little is known about the psychosocial wellbeing of patients with breast cancer following surgery in Sub-Saharan Africa.
View Article and Find Full Text PDFEur Heart J
February 2025
EURObservational Research Programme, European Society of Cardiology, Sophia-Antipolis, France.
Background And Aims: Rheumatic heart disease is the commonest acquired cardiovascular disease worldwide. About 20 years have elapsed since the original Euro Heart Survey on valvular heart disease (VHD) was conducted with multiple changes in practice due to advances in treatment techniques. In this study, we aimed to analyse the management of patients with severe native valve disease or those with previous valvular intervention in comparison with existing European Society of Cardiology guidelines.
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