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Adverse Effects of Intraparenchymal and Peritumoral Application of Isosulfan Blue Dye in Sentinel Lymph Node Mapping in Breast Cancer: A Systematic Review and Meta-Analysis.
Eur J Breast Health
January 2025
Department of General Surgery, Barking Havering and Redbridge University NHS Trust, London, England, United Kingdom.
We investigate the evidence for adverse effects of intraparenchymal and peritumoral application of isosulfan blue dye in sentinel lymph node (SLN) mapping in breast cancer patients. A meta-analysis on the adverse effects of intraparenchymal and peritumoral application of isosulfan application in SLN mapping was conducted using Medline and Embase databases up to 2023. Procedure-based adverse reactions were divided into three grades: Grade I (allergic skin reactions), Grade II (hypotension) and Grade III (requiring vasopressor support).
View Article and Find Full Text PDFEvaluating the Safety and Effectiveness of Regional Upper GI Bleed Services Through an Outcome-Based Analysis at a Centre in the United Kingdom.
Cureus
December 2024
Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, GBR.
Background The aim of this study was to compare the clinical characteristics and clinical outcomes of patients who presented with acute upper gastrointestinal bleeding (AUGIB) among two groups of patients who were transferred from local and district hospitals for endoscopy and subsequent management versus direct admissions to the emergency department with AUGIB to the Sheffield University Hospital NHS Trust. Methods We included 259 patients who underwent upper GI endoscopy from April 2018 to March 2022, of whom 29 were transferred and 230 were direct admissions. The analysis focused on demographics, pathological findings, time to endoscopy, blood transfusions, and hospital stay.
View Article and Find Full Text PDFManagement of Scapula Fractures at a Level 1 Trauma Centre in the United Kingdom.
Cureus
December 2024
Trauma and Orthopaedics, Barts Health NHS Trust, London, GBR.
Background Scapular fractures, an uncommon injury that can be brought on by a high-energy mechanism because of its proximity to the pectoral and shoulder muscles, are frequently linked to fatal injuries. This study aimed to compare surgical versus conservative treatment of scapular fractures and the results of treated patients. Methods The traumatic scapular fracture patients in this cross-sectional study (n = 391) were treated at a major trauma centre (level 1) in the United Kingdom between 2012 and 2018.
View Article and Find Full Text PDFObjectives: The objective of this study is to compare the early oncological outcomes of delayed (>90 days) versus scheduled (≤90 days) radical prostatectomy (RP).
Patients And Methods: Patients with prostate cancer due to undergo surgery between March 2020 and June 2020 who were enrolled in the COVIDSurg-Cancer international, observational study were prospectively followed up for 1 year. Time to surgery was defined as the difference between the operation date and the multi-disciplinary team decision to offer surgery.
Evaluation of intestinal biopsy tissue preservation methods to facilitate large-scale mucosal microbiota research.
EBioMedicine
December 2024
Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Gastroenterology, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom. Electronic address:
Background: Large-scale multicentre studies are needed to understand complex relationships between the gut microbiota, health and disease. Interrogating the mucosal microbiota may identify important biology not captured by stool analysis. Gold standard tissue cryopreservation ('flash freezing') limits large-scale study feasibility.
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