AI Article Synopsis
- "Fairy rings" are circles of mushrooms caused by fungi that stimulate plant growth worldwide.
- In 2010, a compound called 2-azahypoxanthine (AHX) from the fungus Lepista sordida was identified as the key molecule responsible for this growth.
- The study revealed that AHX is produced from 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) through a novel metabolic pathway, showing that feeding L. sordida AICAR leads to increased AHX levels and transcriptional changes in relevant genes.
Article Abstract
"Fairy rings" resulting from fungus-stimulated plant growth occur all over the world. In 2010, 2-azahypoxanthine (AHX) from a fungus Lepista sordida was identified as the "fairy" that stimulates plant growth. Furthermore, 2-aza-8-oxohypoxanthine (AOH) was isolated as a common metabolite of AHX in plants, and the endogenous existence of AHX and AOH in plants was proved. The structure of AHX allowed us to hypothesize that AHX was derived from 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR). Thus, we performed a feeding experiment that supplied AICAR to L. sordida. Consumption of AICAR and accumulation of AHX were observed after feeding. The mycelia extract had enzymatic activity of adenine/5-aminoimidazole-4-carboxamide phosphoribosyltransferase (APRT). APRT gene of L. sordida revealed its structural characteristics in homology modeling and showed transcriptional enhancement after feeding. These results support that AHX was synthesized from AICAR and AHX biosynthesis was transcriptionally controlled by AICAR, indicating the presence of novel purine metabolic pathway in L. sordida.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171910 | PMC |
| http://dx.doi.org/10.1038/srep39087 | DOI Listing |
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