AI Article Synopsis
- - Mitochondrial dysfunction may play a role in conditions like chronic fatigue syndrome (CFS) and schizophrenia, as suggested by a study on a family with these health issues.
- - The family members exhibited abnormal mitochondrial characteristics, including higher blood lactate levels and lower mtDNA content, compared to healthy individuals.
- - Despite showing signs of mtDNA depletion, the researchers did not find any specific mutations in mtDNA or related nuclear genes, although certain genetic variants warrant further investigation.
Article Abstract
Mitochondrial impairment is hypothesized to be involved in chronic fatigue syndrome (CFS) and schizophrenia. We performed a clinical, genetic and functional mitochondrial study in a family consisting of a female presenting schizophrenia in addition to CFS symptoms and her mother and older sister, both presenting with CFS. The three family members showed higher blood lactate levels, higher mitochondrial mass, lower mtDNA content and overall lower mitochondrial enzymatic activities and lower oxygen consumption capacities than healthy women. This family presented mtDNA depletion; however, no mutation was identified neither in the mtDNA nor in the nuclear genes related with mtDNA depletion, even though C16179A and T16519A variants should be further studied.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.mito.2016.10.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!