The aim of this study is to assess the value of the most common tests which can be used in epidemiological surveys to identify asthmatic children. We reviewed anamnestic information from a self-administered questionnaire, bronchial reactivity by means of exercise-test, bronchodilation-test with trimethochinol, carbachol-test (PD20 FEV1 was reported), cutaneous reactivity monitored by prick-test. (Data from a polycentric epidemiological study). We conclude that, while these tests are very useful in the initial study and in the further follow-up of the asthmatic child, providing also information about the possibilities of management of bronchoconstriction and its pharmacologic prevention, they show a limited value in the absolute diagnosis of asthma.
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Biomedicines
January 2025
Department of Immunology, The Fourth Military Medical University, Xi'an 710032, China.
The tumor microenvironment (TME) plays a crucial role in the progression of lung adenocarcinoma (LUAD). However, understanding its dynamic immune and stromal modulation remains a complex challenge. We utilized the ESTIMATE algorithm to evaluate the immune and stromal components of the LUAD TME from the TCGA database.
View Article and Find Full Text PDFAnn Vasc Surg
January 2025
Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:
Introduction: Aorto-bronchial or aorto-pulmonary fistulas (ABPF) are a rare but life-threatening complication following thoracic endovascular aortic repair (TEVAR). This narrative review aims to provide an overview of the current trends and available evidence on ABPF following TEVAR, evaluating risk factors, diagnostic approaches, and possible preventive and therapeutic strategies.
Methods: Relevant publications on post-TEVAR ABPF were selected through a literature search on PubMed.
J Microbiol Biotechnol
December 2024
Institute of Agricultural Science and Technology, Kyungpook National University, Daegu 41566, Republic of Korea.
L. (noni) is native to the tropical and semitropical areas and has been commercially available in health food stores and chain grocery stores specializing in natural foods, recently. Noni seeds are discarded as waste products through the industrial production of noni juice even though their bioactivity components might be a potential source of functional foods.
View Article and Find Full Text PDFSci Total Environ
January 2025
Engineering Research Center of Optical Instrument and System, The Ministry of Education, Shanghai Key Laboratory of Modern Optical System, Shanghai Engineering Research Center of Environmental Biosafety Instruments and Equipment, University of Shanghai for Science and Technology, Shanghai 200093, PR China; Shanghai Institute of Intelligent Science and Technology, Tongji University, Shanghai 200092, PR China.
Metal-Organic Frameworks (MOFs) have shown great promise in environmental protection, owing to their exceptional properties including ultrahigh surface area and porosity, tunable pore size, and easy chemical functionalization. However, emerging evidence from experimental studies indicates that MOFs have side effects on human health due to metal ions doping, resulting in excessive reactive oxygen species (ROS) production, pro-inflammatory responses, and liver fibrosis. In this study, we investigated the impact of MOF-199 on human bronchial epithelial (HBE) cells by using transcriptome sequencing analysis.
View Article and Find Full Text PDFHeliyon
January 2025
Université de Reims Champagne-Ardenne, INSERM, P3Cell UMR-S1250, Reims, France.
Hedgehog (HH) pathway is involved in pulmonary development and lung homeostasis. It orchestrates airway epithelial cell (AEC) differentiation and contributes to respiratory pathogenesis. The core elements Gli2, Smo, and Shh were found altered in the bronchial epithelium of patients with chronic obstructive pulmonary disease (COPD).
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