AI Article Synopsis
- Anti-CarP antibodies were found in 37.9% of rheumatoid arthritis (RA) patients, while ACPA and RF were present in 61.4% and 65.3% of patients, respectively.
- Only a small percentage of healthy individuals showed positive results for these antibodies: 2.04% for anti-CarP, 1.02% for ACPA, and 3.06% for RF.
- Among disease controls, anti-CarP was found in 16.5% of patients, with higher positivity rates observed in those with systemic lupus erythematosus (16.8%) and Sjögren syndrome (31.1%).
Article Abstract
Anti-CarP antibodies were detected in 117 patients with RA (37.9%), ACPA in 190 patients (61.4%) and RF in 202 patients (65.3%). Two (2.04%) of the NHS were positive for anti-CarP, one NHS (1.02%) was positive for ACPA and three NHS were positive for RF (3.06%). Among disease controls, anti-CarP antibodies were detected in 33 patients (16.5%), ACPA in 29 patients (14.5%) and RF in 64 patients (32%). In particular, 16.8% of patients with systemic lupus erythematosus and 31.1% of patients with Sjögren syndrome were positive for anti-CarP. The sensitivity of anti-CarP, ACPA and RF was 46.8, 61.8 and 64.4%, respectively and specificity was 91.95, 89.93 and 76.51%, respectively.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159989 | PMC |
| http://dx.doi.org/10.1186/s13075-016-1205-9 | DOI Listing |
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