It was shown that irregular fluorographic examinations, undetected pathological processes on fluorograms and their erroneous interpretation were the causes of destructive tuberculosis of the lung. Early detection of tuberculosis was hampered by prior nonspecific diseases of the respiratory organs and underestimation of the process activity especially when chronic bronchopulmonary diseases were associated with residual signs of cured tuberculosis. Recommendations for prophylaxis of destructive tuberculosis of the lung are presented.
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World J Orthop
January 2025
Department of Orthopedics, The 940 Hospital of Joint Logistic Support Force of Chinese People's Liberation Army, Lanzhou 730000, Gansu Province, China.
Background: Tuberculosis is among the most devastating infectious diseases worldwide. Spinal tuberculosis is not easy to detect at an early stage, which without effective treatment often leads to spinal deformity and spinal cord damage which in turn cause complications such as paraplegia and quadriplegia. In this study, we established a model using three concentrations of bacteria and carried out a comprehensive evaluation of the model by imaging, general observations, and histopathological and bacteriological studies.
View Article and Find Full Text PDFACS Appl Bio Mater
January 2025
Institute of Nano Science and Technology (INST), Sector-81, Mohali, Punjab 140306, India.
Tuberculosis (TB) triggers a robust immune response, which leads to significant destruction of the lung tissue at the site of infection, aiding in the transmission of (Mtb) to the hosts. The excessive inflammatory response contributes heavily to extracellular matrix (ECM) damage, which is linked to high mortality rates among TB patients. Matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, are pivotal in the breakdown of the ECM, worsening tissue destruction.
View Article and Find Full Text PDFCureus
December 2024
Radiology, Midland Metropolitan University Hospital, Birmingham, GBR.
Tuberculosis is a disease caused by (TB), demonstrating a vast clinical spectrum that can potentially involve all systems of the body. We present the case of a female in her late 20s, with an employment background in healthcare. She recently moved to the UK from India.
View Article and Find Full Text PDFSpine J
January 2025
Seth G. S. Medical College and K. E. M. Hospital, Mumbai, Maharashtra, India, Department of Orthopaedics.
Background Context: On radiopathological examination of spinal tuberculosis (TB), two predominant forms are known: dry and wet types. Wet TB, as the name suggests, has abscess formation as its predominant presenting feature and is the exudative form; dry TB includes caseation and sequestration with minimal exudate. Dry TB often exhibits poorer recovery patterns than the wet counterparts, which can be possibly ascribed to vasculitis, ischemia, or tubercular myelitis, rather than isolated mechanical compression.
View Article and Find Full Text PDFBMC Musculoskelet Disord
January 2025
Department of Joint Surgery, The Second Hospital of Jilin University, Changchun, 130,000, Jilin Province, China.
Objectives: Tuberculosis of the hip joint is a common form of bone tuberculosis that can cause severe joint destruction and affect quality of life. Total hip arthroplasty (THA) is an important way to treat hip joint-related diseases. In recent years, THA has been applied to treat tuberculosis of the hip joint and has achieved certain results.
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