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Engineered extracellular vesicles with DR5 agonistic scFvs simultaneously target tumor and immunosuppressive stromal cells.
Sci Adv
January 2025
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Small extracellular vesicles (sEVs) are nanosized vesicles. Death receptor 5 (DR5) mediates extrinsic apoptosis. We engineer DR5 agonistic single-chain variable fragment (scFv) expression on the surface of sEVs derived from natural killer cells.
View Article and Find Full Text PDFEssential oil and phenolic compounds in different organs and developmental stages of Monarda didyma L., and their biological activity.
Planta
January 2025
Department of Vegetable and Medicinal Plants, Institute of Horticulture Sciences, Warsaw University of Life Sciences, 159 Nowoursynowska Street, 02-776, Warsaw, Poland.
Plant development has a greater impact on the chemical composition of inflorescences than of the leaves and stems of Monarda didyma plants. Monarda didyma L. is a well-known ornamental and aromatic plant.
View Article and Find Full Text PDFBehavior of Typhlodromus (Anthoseius) recki confronted to a combination of plants and food: pollen, Tetranychus urticae and Aculops lycopersici for companion plant use.
Exp Appl Acarol
January 2025
CBGP, Institut Agro Montpellier, INRAE, CIRAD, IRD, Univ. Montpellier, Montpellier, France.
Typhlodromus (Anthoseius) recki feeds on pest mites on tomato plants and its introduction into crops via companion plants, Mentha suaveolens and Phlomis fruticosa, has been recently investigated. This study aims at assessing the predator arrestment behavior, through lab choice tests to determine the effects of (i) prey (Aculops lycopersici and Tetranychus urticae) vs Typha angustifolia pollen deposited on companion plant or Solanum nigrum, (ii) T. urticae vs A.
View Article and Find Full Text PDFAssessing Clinical Improvement of Infants Hospitalized for Respiratory Syncytial Virus-Related Critical Illness.
J Infect Dis
January 2025
Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Background: Pediatric respiratory syncytial virus (RSV)-related acute lower respiratory tract infection (LRTI) commonly requires hospitalization. The Clinical Progression Scale Pediatrics (CPS-Ped) measures level of respiratory support and degree of hypoxia across a range of disease severity, but it has not been applied in infants hospitalized with severe RSV-LRTI.
Methods: We analyzed data from a prospective surveillance registry of infants hospitalized for RSV-related complications across 39 U.
Ginsenoside, a potential natural product against liver diseases: a comprehensive review from molecular mechanisms to application.
Crit Rev Food Sci Nutr
January 2025
Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, Biotech & Biomed Research Institute, School of Chemical Engineering, Northwest University, Xi'an, China.
Liver disease constitutes a significant cause of global mortality, with its pathogenesis being multifaceted. Identifying effective pharmacological and preventive strategies is imperative for liver protection. Ginsenosides, the major bioactive compounds found in ginseng, exhibit multiple pharmacological activities including protection against liver-related diseases by mitigating liver fat accumulation and inflammation, preventing hepatic fibrosis, and exerting anti-hepatocarcinogenic effects.
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