Boiling enriches the linear polysulfides and the hydrogen sulfide-releasing activity of garlic.

Food Chem

Food Science and Technology Programme, Department of Chemistry, National University of Singapore, 117543 Singapore, Singapore; National University of Singapore (Suzhou) Research Institute, 377 Lin Quan Street, Suzhou Industrial Park, Jiangsu 215123, China. Electronic address:

Published: April 2017

Garlic is rich in polysulfides, and some of them can be HS donors. This study was conducted to explore the effect of cooking on garlic's organopolysulfides and HS-releasing activity. Garlic bulbs were crushed and boiled for a period ranging from 3 to 30min and the solvent extracts were analyzed by GC-MS/FID and HPLC. A cell-based assay was used to measure the HS-releasing activity of the extracts. Results showed that the amounts of allyl polysulfides increased in crushed garlic boiled for 6-10min; however, prolonging the thermal treatment to 20 or 30min decreased their concentrations. Data of the HS-releasing activity, expressed as diallyl trisulfide equivalents (DATS-E), parallel this trend, being significantly higher at 6 and 10min boiling. Our results showed enhancement of HS-releasing activity upon moderate boiling, suggesting that shorter cooking time may maximize its health benefits as a dietary source of natural HS donors.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.foodchem.2016.10.076DOI Listing

Publication Analysis

Top Keywords

hs-releasing activity
16
activity garlic
8
activity
5
boiling enriches
4
enriches linear
4
linear polysulfides
4
polysulfides hydrogen
4
hydrogen sulfide-releasing
4
sulfide-releasing activity
4
garlic
4

Similar Publications

In Vivo Environment-Adaptive Nanocomplex with Tumor Cell-Specific Cytotoxicity Enhances T Cells Infiltration and Improves Cancer Therapy.

Small

October 2019

State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China.

Drug delivery strategies possessing selectivity for cancer cells are eagerly needed in therapy of metastatic breast cancer. In this study, the chemotherapeutic agent, docetaxel (DTX), is conjugated onto heparan sulfate (HS). Aspirin (ASP), which has the activity of anti-metastasis and enhancing T cells infiltration in tumors, is encapsulated into the HS-DTX micelle.

View Article and Find Full Text PDF

Hydrogen sulfide (HS) has been recognized as the third gaseous transmitter alongside nitric oxide and carbon monoxide. In the past decade, numerous studies have demonstrated an active role of HS in the context of cancer biology. The three HS-producing enzymes, namely cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3MST), have been found to be highly expressed in numerous types of cancer.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!