AI Article Synopsis
- TCMPs from tomato fruit have shown anti-angiogenic effects by inhibiting endothelial cell movement and resist degradation by gut enzymes.
- After testing with Caco-2 cells, about 37.73% of TCMPs were absorbed without harming the cell layer.
- Purified TCMPs from tomato paste maintained their resistance to digestion and their ability to inhibit cell migration, indicating their potential for drug development.
Article Abstract
The cystine-knot miniproteins present in tomato fruit (TCMPs) have been shown to exert anti-angiogenic effects by inhibiting endothelial cell migration and to display resistance to gastrointestinal proteolytic attack. To better define the pharmacological potential of TCMPs, their oral bioavailability and their resistance to industrial processing must be assessed. To explore the intestinal transport of TCMPs we used the differentiated Caco-2 cells model. After 24h incubation, 37.73±9.34% of TCMPs crossed the epithelium, without altering the integrity of the cell layer. To assess the effects of the industrial processing on the biochemical features and the biological activity of TCMPs, we developed a method for purifying the proteins from tomato paste. The tomato-paste purified TCMPs retained the resistance to gastrointestinal digestion and the inhibitory activity towards endothelial cell migration. Our previous and present results collectively demonstrate that TCMPs possess interesting features for drug development.
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| http://dx.doi.org/10.1016/j.foodchem.2016.11.020 | DOI Listing |
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