AI Article Synopsis
- * Performing this reaction on a solid support helps overcome these selectivity issues, resulting in higher purity and yield of the desired products.
- * The study demonstrates the application of this solid-supported method to synthesize natural products, which were then tested for antibacterial properties, showcasing its practical benefits.
Article Abstract
The Glaser-Hay coupling of terminal alkynes is a useful synthetic reaction for the preparation of polyynes; however, chemoselectivity issues have precluded its widespread utilization. Conducting the reaction on a solid-support provides a mechanism to alleviate the chemoselectivity issues and provide products in high purities and yields. Moreover, the polyyne core is a key component to several natural products. Herein, we describe the application of a solid-supported Glaser-Hay reaction in the preparation of several natural products. These compounds were then screened for antibacterial activity, illustrating the utility of the methodology.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455993 | PMC |
| http://dx.doi.org/10.1021/acs.joc.6b02407 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!