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Cell-Type-Specific ROS-AKT/mTOR-Autophagy Interplay-Should It Be Addressed in Periimplantitis?
Diagnostics (Basel)
December 2024
National Institute of Public Health, General Medicine Faculty, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Periimplantitis represents an inflammatory disease of the soft and hard tissues surrounding the osseointegrated dental implant, triggering progressive damage to the alveolar bone. Cumulative data have revealed that periimplantitis plays a crucial part in implant failure. Due to the strategic roles of autophagy and its upstream coordinator, the AKT/mTOR pathway, in inflammatory responses, the crosstalk between them in the context of periimplantitis should become a key research target, as it opens up an area of interesting data with clinical significance.
View Article and Find Full Text PDFDelivering family centred services in child-onset disability: a mixed methods approach to understanding health professionals' experiences and approaches.
Disabil Rehabil
January 2025
Department of Pediatrics, University of Melbourne, Melbourne, Australia.
Aim: Family-centred service aims to build family capacity to support their children, but behaviours supporting capacity-building vary. We explored what influences the way service providers think about and approach family-centred service.
Method: An online survey drew on experiences, beliefs, and perspectives of Australian providers.
Infrastructuring Educational Genomics: Associations, Architectures, and Apparatuses.
Postdigit Sci Educ
February 2024
University of Birmingham, Birmingham, UK.
Technoscientific transformations in molecular genomics have begun to influence knowledge production in education. Interdisciplinary scientific consortia are seeking to identify 'genetic influences' on 'educationally relevant' traits, behaviors, and outcomes. This article examines the emerging 'knowledge infrastructure' of educational genomics, attending to the assembly and choreography of organizational associations, epistemic architecture, and technoscientific apparatuses implicated in the generation of genomic understandings from masses of bioinformation.
View Article and Find Full Text PDFThe Macklin Effect Following Trauma: A Case Report of Concurrent Pneumothorax, Pneumoperitoneum, Pneumomediastinum, and Pneumoretroperitoneum in an Intubated Young Adult.
Cureus
December 2024
Department of Trauma Surgery, King Saud Medical City, Riyadh, SAU.
Article Synopsis
- Pneumomediastinum, often occurring silently post-trauma, complicates diagnoses especially when paired with other conditions like pneumothorax and pneumoperitoneum, largely due to the Macklin effect where air escapes from ruptured alveoli.
- An 18-year-old male involved in a car crash was found with severe pneumothorax and subcutaneous emphysema but showed no signs of significant esophageal or bronchial injury upon further evaluation.
- Despite alarming initial imaging, the patient's treatment was conservative, allowing for a gradual healing process and eventual discharge without complications, illustrating the need for careful assessment in trauma management.
Nurses' Workplace Violence Reporting Behaviours and Reasons for Not Formally Reporting: A Cross-Sectional Secondary Analysis.
J Clin Nurs
December 2024
School of Nursing, University of British Columbia, Vancouver, Canada.
Aim: To investigate predictors of nurses' reporting behaviours and their reasons for not formally reporting.
Background: Underreporting of workplace violence (WPV) among nurses contributes to gaps in WPV prevention measures, as it cannot be fully understood. WPV is classified according to its source (Type II: patients and visitors, Type III: coworkers) and forms (physical assault, threat of assault, emotional abuse, verbal sexual harassment and sexual assault).
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