Introduction: No data are available for normative values of cutaneous threshold and spatial discrimination in the feet. We developed clinically applicable reference values in relation to the nerve distributions of the feet.
Methods: We determined foot sensation in 196 healthy individuals. Cutaneous threshold (1-point static discrimination, S1PD) was tested with monofilaments (0.008 to 300 gram) and spatial discrimination (2-point static [S2PD] and moving [M2PD] discrimination) on five locations per foot.
Results: There was a significant age-dependent increase in S1PD, S2PD, and M2PD values (P < 0.05). No significant differences were found between both feet. S1PD values differed up to 0.8 g between genders. There were no significant differences between genders for S2PD and M2PD measurements. M2PD values were generally lower than S2PD values.
Conclusions: This study provides age-related normative values for foot sensation to help clinicians assess sensory deficits in relation to aging and identify patients with underlying nerve problems. Muscle Nerve 56: 399-407, 2017.
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http://dx.doi.org/10.1002/mus.25512 | DOI Listing |
Int J Infect Dis
January 2025
Koç University-Isbank Center for Infectious Diseases, Istanbul, Turkey; Department of Infectious Diseases, Koç University School of Medicine, Istanbul, Turkey. Electronic address:
Objectives: This study identifies key risk factors for fatality among adult tetanus patients and assesses the impact of vaccination status and antibody levels on disease severity and outcomes in tetanus cases. Despite widespread vaccination, fatality rates remain high due to diagnostic and management challenges.
Design/methods: A meta-analysis of 182 tetanus cases from 36 countries, published since 1990, was conducted.
J Electromyogr Kinesiol
February 2025
Department of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Road E, Guelph, ON N1G 2W1, Canada. Electronic address:
Rate of torque development (RTD) measures how rapidly one can generate torque and is crucial for balance and athletic performance. Fast RTD depends on the rapid recruitment of high threshold motor units (MUs). Cutaneous electrical stimulation has been shown to alter MU excitability, favoring high threshold MUs via reduced recruitment thresholds.
View Article and Find Full Text PDFTrop Med Int Health
January 2025
Programa de Pós-graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Objectives: The purpose of this study was to determine reference points for thermal perception in cutaneous lesions of leprosy, a disease caused by Mycobacterium leprae characterised by hypoesthesia in skin lesions due to nerve and Schwann cell infection. Early diagnosis is essential to control transmission and effectively treat the disease.
Methods: Quantitative thermal testing (QTT) has been proposed as a valuable tool for early detection of the disease, initiation of treatment, and monitoring of nerve damage.
Eur Geriatr Med
January 2025
Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan.
Purpose: A relationship between decreased plantar cutaneous sensation and impaired balance function has been reported in patients with peripheral neuropathy and diabetes. This cross-sectional study aimed to investigate the relationship between plantar sensation and postural balance, as well as the association between plantar sensation and sarcopenia-related motor function in community-dwelling older adults.
Methods: The participants included 1659 community-dwelling older adults with a mean age of 74 ± 5 years, of which 43% were male patients.
J Skin Cancer
December 2024
Scientific Department, Medical Laboratory CSD, Kyiv, Ukraine.
Point mutations at codon 600 of the BRAF oncogene are the most common alterations in cutaneous melanoma (CM). Assessment of BRAF status allows to personalize patient management, though the affordability of molecular testing is limited in some countries. This study aimed to develop a model for predicting alteration in BRAF based on routinely available clinical and histological data.
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