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Distal Limb Patterning Requires Modulation of cis-Regulatory Activities by HOX13. | LitMetric

Distal Limb Patterning Requires Modulation of cis-Regulatory Activities by HOX13.

Cell Rep

Laboratory of Genetics and Development, Institut de Recherches Cliniques de Montréal (IRCM), 110 avenue des Pins Ouest, Montréal, QC H2W1R7, Canada; Department of Medicine, Université de Montréal, Montréal, H3T1J4 QC, Canada. Electronic address:

Published: December 2016

The combinatorial expression of Hox genes along the body axes is a major determinant of cell fate and plays a pivotal role in generating the animal body plan. Loss of HOXA13 and HOXD13 transcription factors (HOX13) leads to digit agenesis in mice, but how HOX13 proteins regulate transcriptional outcomes and confer identity to the distal-most limb cells has remained elusive. Here, we report on the genome-wide profiling of HOXA13 and HOXD13 in vivo binding and changes of the transcriptome and chromatin state in the transition from the early to the late-distal limb developmental program, as well as in Hoxa13; Hoxd13 limbs. Our results show that proper termination of the early limb transcriptional program and activation of the late-distal limb program are coordinated by the dual action of HOX13 on cis-regulatory modules.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697718PMC
http://dx.doi.org/10.1016/j.celrep.2016.11.039DOI Listing

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