Tauopathies are neurodegenerative disorders that affect distinct brain regions, progress at different rates, and exhibit specific patterns of tau accumulation. The source of this diversity is unknown. We previously characterized two tau strains that stably maintain unique conformations in vitro and in vivo, but did not determine the relationship of each strain to parameters that discriminate between tauopathies such as regional vulnerability or rate of spread. We have now isolated and characterized 18 tau strains in cells based on detailed biochemical and biological criteria. Inoculation of PS19 transgenic tau (P301S) mice with these strains causes strain-specific intracellular pathology in distinct cell types and brain regions, and induces different rates of network propagation. In this system, strains alone are sufficient to account for diverse neuropathological presentations, similar to those that define human tauopathies. Further study of these strains can thus establish a structural logic that governs these biological effects.
Background: This study examines the relationship between unmet healthcare needs and employment status, with a focus on how this relationship was influenced by the Spanish economic recession of 2008-2012.
Methods: Data were obtained from the Spanish National Health Survey for 2006 and 2011-2012. The outcome variable was the presence of unmet healthcare needs, describing its reasons.
Centro de Investigaciones Biológicas, Área Académica de Biología, Instituto de Ciencias Básicas e Ingenierías, Universidad Autónoma del Estado de Hidalgo, México.
A health risk assessment was carried out to determine the probability of damage and carcinogenic effects from consumption of five mushroom species (Boletus edulis, Cantharellus cibarius, Lactarius indigo, Ramaria flava, and Sarcodon calvatus) potentially contaminated by chromium (Cr), based on data reported by López-Vázquez and Prieto-García (2016) in Hidalgo state [López-Vázquez E, Prieto-García F. Minerals and toxic elements in wild mushrooms species from regions of Hidalgo state in Mexico. Asian J Chem.
Introduction: The development of stress-related psychopathologies, often associated with socio-emotional dysfunctions, is crucially determined by genetic and environmental factors, which shape the individual vulnerability or resilience to stress. Especially early adolescence is considered a vulnerable time for the development of psychopathologies. Various mouse strains are known to age-dependently differ in social, emotional, and endocrine stress responses based on genetic and epigenetic differences.
The Dinaric Karst extends along the Adriatic coast of the Western Balkan Peninsula and is home to a group of "karst minnows" of the genera , , and , which have adapted to the highly variable water conditions in the karst by spending up to several months underground, but require surface habitats for spawning, defining them as substygophiles. The three species of the genus , , , and , are defined by restricted ranges, making them vulnerable to pollution and extended draughts caused by the climate change. In this study, the phylogeny of Leusciscinae was reconstructed using 15 and one , one , and one complete mitochondrial genomes and the position of the genus within the subfamily as sister species to the clade was confirmed.
