Phase change materials (PCMs) are highly attractive for nonvolatile electrical and all-optical memory applications because of unique features such as ultrafast and reversible phase transitions, long-term endurance, and high scalability to nanoscale dimensions. Understanding their transient characteristics upon phase transition in both the electrical and the optical domains is essential for using PCMs in future multifunctional optoelectronic circuits. Here, we use a PCM nanowire embedded into a nanophotonic circuit to study switching dynamics in mixed-mode operation. Evanescent coupling between light traveling along waveguides and a phase-change nanowire enables reversible phase transition between amorphous and crystalline states. We perform time-resolved measurements of the transient change in both the optical transmission and resistance of the nanowire and show reversible switching operations in both the optical and the electrical domains. Our results pave the way toward on-chip multifunctional optoelectronic integrated devices, waveguide integrated memories, and hybrid processing applications.
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Anal Chim Acta
February 2025
Department of Chemistry, University of Waterloo, Waterloo, ON, Canada. Electronic address:
Background: Normothermic ex situ heart perfusion (ESHP) has emerged as a valid modality for advanced cardiac allograft preservation and conditioning prior to transplantation though myocardial function declines gradually during ESHP thus limiting its potential for expanding the donor pool. Recently, the utilization of dialysis has been shown to preserve myocardial and coronary vasomotor function. Herein, we sought to determine the changes in myocardial metabolism that could support this improvement.
View Article and Find Full Text PDFJ Chromatogr A
January 2025
Genetics Guided Dementia Discovery (G2D2), Eisai, Inc. 35 Cambridge Park Drive, Suite 200, Cambridge, MA, 02140, USA.
The current study investigates the use of mixed-mode chromatography as a combination of anion-exchange (AEX) and hydrophobic interaction chromatography (HIC) for the analysis and purification of single-stranded antisense oligonucleotides with stereo-controlled phosphorothioate inter- nucleotide linkages. Initially a Scherzo-SS-C18 trimodal stationary phase with reversed-phase/AEX/ cation-exchange (CEX) functionalities is systematically evaluated to reveal the presence of U-shaped retention composed of two retention modes namely AEX and HIC, where the latter was also observed on related trimodal Scherzo SM and SW analogues. For the first time, retention and separation of deprotected oligonucleotides was described on a single mixed-mode column using a combination of AEX and HIC.
View Article and Find Full Text PDFHeliyon
December 2024
Department of Mathematics and Statistics, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Using discrete fractional calculus, a wide variety of physiological phenomena with various time scales have been productively investigated. In order to comprehend the intricate dynamics and activity of neuronal processing, we investigate the behavior of a slow-fast FitzHugh-Rinzel (FH-R) simulation neuron that is driven by physiological considerations via the Caputo fractional difference scheme. Taking into account the discrete fractional commensurate and incommensurate mechanisms, we speculate on the numerical representations of various excitabilities and persistent activation reactions brought about by the administered stimulation.
View Article and Find Full Text PDFDemography
December 2024
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
The evaluation of innovative web-based data collection methods that are convenient for the general public and that yield high-quality scientific information for demographic researchers has become critical. Web-based methods are crucial for researchers with nationally representative research objectives but without the resources of larger organizations. The web mode is appealing because it is inexpensive relative to in-person and telephone modes, and it affords a high level of privacy.
View Article and Find Full Text PDFBackground: The COVID-19 pandemic stressed the critical role of diagnostic testing in controlling the spread of infectious diseases. Due to their accessibility and presence in underserved areas, community pharmacies have become vital in decentralizing COVID-19 testing. Despite their potential, pharmacies face significant barriers in integrating testing services.
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