AI Article Synopsis
- Concerted tandem and traveling wave ion mobility mass spectrometry (CTS analysis) creates a detailed four-dimensional dataset that includes key characteristics like ion mass and abundance.
- This innovative nontargeted lipidomics method was applied to analyze phospholipids in human serum using both positive and negative ion modes.
- The study found that combining product ion mobility with unique collisional cross-section values significantly enhances the ability to identify lipids within complex biological samples.
Article Abstract
Concerted tandem and traveling wave ion mobility mass spectrometry (CTS analysis) is a unique method that results in a four-dimensional data set including nominal precursor ion mass, product ion mobility, accurate mass of product ion, and ion abundance. This nontargeted lipidomics CTS approach was applied in both positive- and negative-ion mode to phospholipids present in human serum, and the data set was used to evaluate the value of product ion mobility in identifying lipids in a complex mixture. It was determined that the combination of diagnostic product ions and unique collisional cross-section values of product ions is a powerful tool in the structural identification of lipids in a complex biological sample.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5250582 | PMC |
| http://dx.doi.org/10.1021/acs.analchem.6b04047 | DOI Listing |
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